胎盘组织中IGF-1和IGF-2表达水平与妊娠期糖尿病巨大儿发生的相关研究

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Abstract Objective To explore the correlation of gestational diabetes mellitus (GDM) macrosomia with the expression of insulin-like growth factor-1 (IGF-1) and insulin-like growth factor-2 (IGF-2). Methods Forty neonates with macrosomia given birth by primiparas who were admitted to Department of Obstetrics of the Affiliated Maternity Hospital of Nanjing Medical University from April 2014 to December 2016 and confirmed with GDM were assigned to the GDM macrosomia group, 40 neonates with macrosomia given birth by healthy primiparas over the same period were assigned to the healthy macrosomia group, and 40 neonates with normal weigh given birth by healthy primiparas over the same period were assigned to the control group. The expression of IGF-1 and IGF-2 in the neonate′s placenta was compared between the three groups, and the correlation of IGF-1 and IGF-2 expression with the development of GDM macrosomia was analyzed. Results Expression of IGF-1 and IGF-2 mRNA in placenta was significantly higher in GDM macrosomia group than that in healthy macrosomia group and control group (P < 0.01), and there were no statistically significant differences between healthy macrosomia group and control group in the levels of IGF-1 or IGF-2 mRNA (P > 0.05); binary Logistic regression analysis identified IGF-1 and IGF-2 levels as the risk factors for macrosomia in GDM (OR = 3.490, 95%CI: 2.537-6.928, P = 0.017; OR = 2.077,95%CI: 1.098-4.997, P = 0.023). Conclusion Expression of IGF-1 and IGF-2 in placenta is significantly elevated in patients with GDM macrosomia; expression of IGF-1 and IGF-2 is significantly correlated with the development of GDM macrosomia.

Key words： Gestational diabetes mellitus Giant children Placenta Insulin-like growth factor-1 Insulin-like growth factor-2

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	CAI Manhong CHENG Qing▲

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CAI Manhong CHENG Qing▲. Correlation between expression of IGF-1 and IGF-2 in placenta and the occurrence of gestational diabetes mellitus[J]. 中国医药导报, 2017, 14(30): 112-114,128.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2017/V14/I30/112

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