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| Effect of different dose of tranexamic acid local application on the postoperative drainage of total hip arthroplasty |
| HAO Shenshen LUAN Yanjun LIU Zhibin WANG Fei LIU Yanxiong LIU Jun |
| Department of Orthopedics, Affiliated Hospital of Yan′an University, Shaanxi Province, Yan′an 716000, China |
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Abstract Objective To observe the effect of different dose of tranexamic acid (TXA) topical application on the postoperative drainage of total hip arthroplasty (THA). Methods 75 patients with primary unilateral THA from January to December 2016 were divided into three groups random number table, 25 patients in each group. The group A was treated by retrograde injection of 1.0 g (NS: 100 mL) TXA via the drainage tube when incision was sewed up. Group B and group C were injected with 2.0 g (NS: 100 mL) TXA and 3.0 g (NS: 100 mL) TXA in the same way, respectively. The main observation items were postoperative drainage volume, hemoglobin (Hb) of the third day after operation and number of blood transfusion. The secondary items included operation time, intraoperative blood loss, prothrombin time and activated partial thromboplastin time of the third day after surgery, number of pulmonary embolism, number of deep vein thrombosis and number of infections. Results There was no significant difference among the three groups in the base data (P > 0.05). In the main observation items, the postoperative drainage volume decreased successively; the group A was significantly larger than the group B and the group C respectively (P < 0.05), while the difference between the group B and the group C was not statistically significant (P > 0.05). The Hb of the third day after operation increased successively; group A was significantly lower than group B and group C respectively (P < 0.05), while there was no significant difference between group B and group C (P > 0.05). The incidence of blood transfusion was not statistically significant among the three groups (P > 0.05). There was no significant difference among the three groups in the secondary observation index (P > 0.05). Conclusion The topical application of 2.0 g TXA is superior to 1.0 g TXA in reducing the postoperative drainage volume of THA, but similar to that of 3.0 g TXA. Therefore, it was recommended that 2.0 g TXA is used as a proper dose to decrease the postoperative drainage volume of THA.
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