超声造影结合彩色多普勒超声在评估乳腺癌新辅助化疗效果中的应用

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Abstract Objective To discuss the value in the neoadjuvant chemotherapy for breast cancer with contrast-enhanced ultrasonography and color Doppler ultrasound. Methods From March 2016 to March 2017, 65 cases of breast cancer patients in Chinese and Western Medicine Hospital of Taizhou were selected as the observe object, all patients underwent neoadjuvant chemotherapy (NAC), ultrasound imaging and color Doppler ultrasound (CDFI) examination were used before and after NAC. The value of contrast-enhanced ultrasonography, CDFI ultrasonography and combined application in assessing the efficacy of NAC in breast cancer were observed. Results According to the Miller and Payne pathology classification criteria, all the patients could be divided into chemotherapy (54 cases) and ineffective (11 cases) after NAC treatment. The sensitivity of CDFI was 79.25%, the specificity was 33.33%, the sensitivity of the dual-mode and CDFI ultrasound was 96.23%, the specificity was 75.00%. The accuracy of the dual-mode and ultrasound examination was significantly higher than CDFI, the results of the coherence analysis showed that the Kappa value was 0.664, the patients underwent CEUS before and after NAC. There was no significant difference in time (TTP) and enhancement time (MTT), the differences was not statistically significant (t=1.052, 1.179, all P > 0.05), the peak intensity (PI) and area under the curve were significantly lower after chemotherapy than before NAC, the differences were statistically significant (t = 4.513, 125.631, all P < 0.05), pathological assessment of NAC effective relief of peak intensity changes was significantly higher than ineffective patients, the difference was statistically significant (t = 5.916, P < 0.05). The ROC curve showed that is the most accurate when resolving NAC validity by the peak intensity change rate corresponding to the sum of sensitivity and specificity was used as the cutoff value. Conclusion Dual-mode contrast-enhanced ultrasonography combined with CDFI examination can accurately assess the effect of breast cancer NAC treatment, relative to the CDFI evaluation, the results are more reliable, accurate, it can be widely used in the clinical.

Key words： Contrast-enhanced ultrasonography Color Doppler ultrasonography Breast cancer Neoadjuvant chemotherapy Efficacy evaluation

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	HAN Yanfeng1 ZOU Shuwei2 WANG Baohua3▲

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HAN Yanfeng1 ZOU Shuwei2 WANG Baohua3▲. Application in the evaluation of neoadjuvant chemotherapy for breast cancer with contrast-enhanced ultrasonography combined with color doppler ultrasound[J]. 中国医药导报, 2018, 15(13): 105-108.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I13/105

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