Abstract Objective To investigate effect of macrophages and pulmonary microvascular endothelial cells (HPMVECs) on Aspergillus fumigatus. Methods In vitro models of Aspergillus fumigatus-treated HPMVECs and Aspergillus fumigatus-treated J774 cells were established, confocal laser scanning microscope was used for detection of co-cultures. Results Aspergillus fumigatus were phagocyted by J774 cells. However, Aspergillus fumigatus were not internalized by HPMVECs, onlu morphology change and integrity compromise were observed on Aspergillus fumigatus-treated HPMVECs. Conclusion J774 cells phagocytes Aspergillus fumigatus. HPMVECs can't internalize Aspergillus fumigatus. Aspergillus fumigatus can cause morphology change and integrity compromise in HPMVECs.
SONG Jun HAN Jing SUN Yue SHI Weimin▲. Effect of macrophages and pulmonary microvascular endothelial cells on Aspergillus fumigatus[J]. 中国医药导报, 2018, 15(13): 18-20.
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