体外膜肺氧合在心脏死亡供体肝移植中的应用进展

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Abstract There is an ongoing shortfall of liver organ donor in the development of liver transplantation in the worldwide. Donation after cardiac death (DCD) is an important way to increase the number of liver donors at the present stage. The use of DCD livers was associated with a significantly higher risk of primary nonfunction and ischemic biliary complications because of prolonged warm ischemia time (WIT). It is a paramount research dilemma to devise how to avert or lessen the warm ischemia injury of DCD livers. Extracorporeal membrane oxygenation (ECMO) can minimize the WIT and injuries induced by warm ischemia through providing respiratory and circulatory support and increasing the perfusion of the organ. Moreover, ECMO facilitates safe transfer of potential DCD donors between hospitals and assessment of the potential DCD graft function, thus enhance the potential DCD donation success ratio and success rate of transplantation. Although, there are some ongoing controversies such as the ethical and technical issues about the use of ECMO in liver transplantation using DCD. It is believed that the application of ECMO will be an important measure to promote the development of liver transplantation using DCD with the continuous development of society and technology.

Key words： Liver transplantation Donation after cardiac death Extracorporeal membrane oxygenation Ischemia reperfusion injury

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	MIAO Mengqiu1 MA Xueping1 MAO Fei1 ZUO Xiangrong2

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MIAO Mengqiu1 MA Xueping1 MAO Fei1 ZUO Xiangrong2. Research progress of extracorporeal membrane oxygenation in liver transplantation using donation after cardiac death[J]. 中国医药导报, 2018, 15(12): 28-31.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I12/28

[1] Manyalich M，Nelson H，Delmonico FL. The need and opportunity for donation after circulatory death worldwide [J]. Curr Opin Organ Transplant，2018，23（1）：136-141.
[2] 朱泽斌，赵强，何晓顺. 移植供肝保护新进展[J/CD].中华重症医学电子杂志，2017，3（2）：94-99.
[3] 中华医学会器官移植学分会.中国心脏死亡器官捐献工作指南（第2版）[J].实用器官移植电子杂志，2013，1（1）：9-12.
[4] Blok JJ，Detry O，Putter H，et al. Longterm results of liver transplantation from donation after circulatory death [J]. Liver Transpl，2016，22（8）：1107-1114.
[5] Tejani M，Yi SY，Eudailey KW，et al. Extracorporeal membrane oxygenation as a rescue device for postreperfusion cardiac arrest during liver transplantation [J]. Liver Transpl，2015，21（3）：410-414.
[6] Barrou B，Billault C，Nicolas-Robin A. The use of extracorporeal membranous oxygenation in donors after cardiac death [J]. Curr Opin Organ Transplant，2013，18（2）：148-153.
[7] Net M，Valero R，Almenara R，et al. The effect of normothermic recirculation is mediated by ischemic preconditioning in NHBD liver transplantation [J]. Am J Transplant，2005， 5（10）：2385-2392.
[8] Johnson LB，Plotkin JS，Howell CD，et al. Successful emergency transplantation of a liver allograft from a donor maintained on extracorporeal membrane oxygenation [J]. Transplantation，1997，63（6）：910-911.
[9] 王志为，杨志豪. 心死亡捐献供体器官保护中体外膜肺氧合技术的应用研究进展[J]. 中华临床医师杂志：电子版，2013，7（24）：11614-11618.
[10] Dutkowski P，Polak WG，Muiesan P，et al. First comparison of hypothermic oxygenated perfusion versus static cold storage of human donation after cardiac death liver transplants：an international-matched case analysis [J]. Ann Surg，2015，262（5）：764-770.
[11] Sch?觟n MR，Kollmar O，Wolf S，et al. Liver transplantation after organ preservation with normothermic extracorporeal perfusion [J]. Ann Surg，2001，233（1）：114-123.
[12] Tolboom H，Pouw RE，Izamis ML，et al. Recovery of warm ischemic rat liver grafts by normothermic extracorporeal perfusion [J]. Transplantation，2009，87（2）：170-177.
[13] Noormohamed MS，Kanwar A，Ray C，et al. Extracorporeal membrane oxygenation for resuscitation of deceased cardiac donor livers for hepatocyte isolation [J]. J Surg Res，2013，183（2）：e39-e48.
[14] Magliocca JF，Magee JC，Rowe SA，et al. Extracorporeal support for organ donation after cardiac death effectively expands the donor pool [J]. J Trauma，2005，58（6）：1095-1101.
[15] Rojas-Pena A，Hall CM，Cook KE，et al. Timing of heparin and perfusion temperature during procurement of organs with extracorporeal support in donors after circulatory determination of death [J]. ASAIO J，2011，57（5）：368-374.
[16] Hagiwara M，Matsuno N，Meng LT，et al. Applicability of combined use of extracorporeal support and temperature-controlled machine perfusion preservation for liver procurement of donors after cardiac death in pigs [J]. Transplant Proc，2016，48（4）：1234-1238.
[17] O'Neill S，Roebuck A，Khoo E，et al. A meta-analysis and meta-regression of outcomes including biliary complications in donation after cardiac death liver transplantation [J]. Transpl Int，2014，27（11）：1159-1174.
[18] Fondevila C，Hessheimer AJ，Ruiz A，et al. Liver transplant using donors after unexpected cardiac death：novel preservation protocol and acceptance criteria [J]. Am J Transplant，2007，7（7）：1849-1855.
[19] Jiménez-Galanes S，Meneu-Diaz MJ，Elola-Olaso AM，et al. Liver transplantation using uncontrolled non-heart-beating donors under normothermic extracorporeal membrane oxygenation [J]. Liver Transpl，2009，15（9）：1110-1118.
[20] Pelletier SJ，Hundley JC，Englesbe MJ，et al. Liver transplantation and ECMO-assisted donation after cardiac death [J]. Am J Transplant，2009，9（Suppl 2）：263.
[21] Fondevila C，Hessheimer AJ，Flores E，et al. Applicability and results of Maastricht type 2 donation after cardiac death liver transplantation [J]. Am J Transplant，2012，12（1）：162-170.
[22] Shapey IM，Muiesan P. Regional perfusion by extracorporeal membrane oxygenation of abdominal organs from donors after circulatory death：a systematic review [J]. Liver Transpl，2013，19（12）：1292-1303.
[23] Ortega-Deballon I，Hornby L，Shemie SD. Protocols for uncontrolled donation after circulatory death：a systematic review of international guidelines，practices and transplant outcomes [J]. Crit Care，2015，19：268.
[24] 赵纪强，霍枫，李鹏，等. 中国心脏死亡器官捐献工作发展及影响因素：单中心经验[J].中华移植杂志：电子版，2017，11（1）：32-36.
[25] 何洹，李鹏，屠伟峰.体外膜肺氧合用于潜在心脏死亡供体的院间转运[J].中华器官移植杂志，2013，34（12）：737-739.
[26] 中华医学会器官移植学分会，中华医学会外科学分会移植学组，中国医师协会器官移植医师分会.中国心脏死亡捐献器官评估与应用专家共识[J].兰州大学学报：医学版，2014，40（4）：71-78.
[27] 中华医学会器官移植学分会，中国医师协会器官移植医师分会.体外膜氧合在中国公民逝世后捐献供器官保护中的应用专家共识（2016版）[J].中华移植杂志：电子版，2016，10（3）：107-111.