细菌中谷胱甘肽的研究进展

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Abstract Glutathione is a small molecule peptide that is one of the most abundant thiols present in gram-negative bacteria and most gram-positive bacteria. Some bacteria can synthesis glutathione directly, some may acquire glutathione form external environment. Bacteria encounter various stress conditions from the environment and their own metabolites, such as oxidative stress, osmotic stress and other stresses coming from chlorine compounds, metal ions and so on. Glutathione can protects the bacterial cells from these stress damage directly or indirectly. This article is to review the synthesis, metabolic balance and main roles of Glutathione in bacteria.

Key words： Glutathione Bacteria Homeostasis Antioxidant

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	LI Chenglong1 LIU Xianghong1 WU Yeke2

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LI Chenglong1 LIU Xianghong1 WU Yeke2. Research Progress of Glutathione in Bacteria[J]. 中国医药导报, 2018, 15(12): 21-24.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I12/21

[1] Bathige SD，Umasuthan N，Godahewa GI，et al. Two variants of selenium-dependent glutathione peroxidase from the disk abalone Haliotis discus discus：Molecular characterization and immune responses to bacterial and viral stresses [J]. Fish Shellfish Immunol，2015，45（2）：648-655.
[2] Narainsamy K，Farci S，Braun E，et al. Oxidative-stress detoxification and signalling in cyanobacteria： the crucial glutathione synthesis pathway supports the production of ergothioneine and ophthalmate [J]. Mol Microbiol，2016， 100（1）：15-24.
[3] Gutierrez-Praena D，Pichardo S，Jos A，et al. Alterations observed in the endothelial HUVEC cell line exposed to pure Cylindrospermopsin [J]. Chemosphere，2012，89（9）：1151-1160.
[4] Hopkinson RJ，Leung IK，Smart TJ，et al. Studies on the Glutathione-Dependent Formaldehyde-Activating Enzyme from Paracoccus denitrificans [J]. PLoS One，2015，10（12）：e0145085.
[5] Kumar S，Kasturia N，Sharma A，et al. Redox-dependent stability of the gamma-glutamylcysteine synthetase enzyme of Escherichia coli：a novel means of redox regulation [J]. Biochem J，2013，449（3）：783-794.
[6] Lim B，Pasternak M，Meyer AJ，et al. Restricting glutamylcysteine synthetase activity to the cytosol or glutathione biosynthesis to the plastid is sufficient for normal plant development and stress tolerance [J]. Plant Biol （Stuttg），2014，16（1）：58-67.
[7] Yang Y，Wang W，Huang T，et al. Transgenesis of Tol2-mediated seamlessly constructed BAC mammary gland expression vectors in Mus musculus [J]. J Biotechnol，2016， 218（3）：66-72.
[8] Xu Z，Xie J，Liu J，et al. Whole-genome resequencing of Bacillus cereus and expression of genes functioning in sodium chloride stress [J]. Microb Pathog，2017，104（6）：248-253.
[9] Chauhan AK，Kang SC. Thymol disrupts the membrane integrity of Salmonella ser. typhimurium in vitro and recovers infected macrophages from oxidative stress in an ex vivo model [J]. Res Microbiol，2014，165（7）：559-565.
[10] Krishna G，Gopalakrishnan G，Goel S. In vitro and in vivo genotoxicity assessment of the dopamine receptor antagonist molindone hydrochloride [J]. Environ Mol Mutagen，2016，57（4）：288-298.
[11] Guzman-Guillen R，Prieto Ortega AI，Martin-Camean A，et al. Beneficial effects of vitamin E supplementation against the oxidative stress on Cylindrospermopsin-exposed tilapia（Oreochromis niloticus）[J]. Toxicon，2015，104（3）：34-42.
[12] Stout J，De Vos D，Vergauwen B，et al. Glutathione biosynthesis in bacteria by bifunctional GshF is driven by a modular structure featuring a novel hybrid ATP-grasp fold [J]. J Mol Biol，2012，416（4）：486-494.
[13] Kadiyala M，Ponnusankar S，Elango K. Calotropis gigantiea （L.） R. Br（Apocynaceae）：a phytochemical and pharmacological review [J]. J Ethnopharmacol，2013，150（1）：32-50.
[14] Lu D，Tang G，Wang D，et al. The Sinorhizobium meliloti LysR family transcriptional factor LsrB is involved in regulation of glutathione biosynthesis [J]. Acta Biochim Biophys Sin (Shanghai)，2013，45（10)）：882-888.
[15] Guzman-Guillen R，Prieto AI，Vazquez CM，et al. The protective role of l-carnitine against cylindrospermopsin-induced oxidative stress in tilapia （Oreochromis niloticus）[J]. Aquat Toxicol，2013，132（3）：141-150.
[16] Lee EH，Kim HY，Hwang KY. The GSH- and GSSG-bound structures of glutaredoxin from Clostridium oremlandii [J]. Arch Biochem Biophys，2014，564（4）：20-25.
[17] Zhang J，Quan C，Wang C，et al. Systematic manipulation of glutathione metabolism in Escherichia coli for improved glutathione production [J]. Microb Cell Fact，2016，15（4）：31-38.
[18] van der Stel AX，van Mourik A，Laniewski P，et al. The Campylobacter jejuni RacRS two-component system activates the glutamate synthesis by directly upregulating gamma-glutamyltranspeptidase（GGT）[J]. Front Microbiol，2015，345（6）：561-567.
[19] Chen F，Gao J，Wu D，et al. Clinical and pathologic features of a suspected selenium deficiency in captive plains zebras [J]. Biol Trace Elem Res，2017，176（1）：114-119.
[20] Kirankumar B，Kulkarni GB，Sanjeevkumar S，et al. Influence of DMF-induced oxidative stress on membrane and periplasmic proteins in Paracoccus sp. SKG [J]. Appl Biochem Biotechnol，2014，173（5）：1263-1273.
[21] Lu J，Holmgren A. The thioredoxin antioxidant system [J]. Free Radic Biol Med，2014，66（3）：75-87.
[22] Wang D，Zhu F，Wang Q，et al. Disrupting ROS-protection mechanism allows hydrogen peroxide to accumulate and oxidize Sb（Ⅲ） to Sb（Ⅴ） in Pseudomonas stutzeri TS44 [J]. BMC Microbiol，2016，16（1）：274-279.
[23] Fu RY，Bongers RS，van S，et al. Introducing glutathione biosynthetic capability into Lactococcus lactis subsp. cremoris NZ9000 improves the oxidative-stress resistance of the host [J]. Metab Eng，2006，8（6）：662-671.
[24] Fujisawa M，Ito M，Krulwich TA. Three two-component transporters with channel-like properties have monovalent cation/proton antiport activity [J]. Proc Natl Acad Sci USA，2007，104（33）：13289-13294.
[25] Healy J，Ekkerman S，Pliotas C，et al. Understanding the structural requirements for activators of the Kef bacterial potassium efflux system [J]. Biochemistry，2014，53（12）：1982-1992.
[26] Iantomasi T，Favilli F，Vincenzini MT. Evidence of glutathione transporter in rat brain synaptosomal membrane vesicles [J]. Neurochem Int，1999，34（6）：509-516.
[27] Dhar MS，Gupta V，Virdi JS. Detection，distribution and characterization of novel superoxide dismutases from Yersinia enterocolitica Biovar 1A [J]. PLoS One，2013，8（5）：e63919.
[28] Carneiro M，Reis B，Azevedo J，et al. Glutathione Transferases responses induced by microcystin-lr in the gills and hepatopancreas of the clam venerupis philippinarum [J]. Toxins（Basel），2015，7（6）：2096-2120.
[29] Lemke LS，Chura-Chambi RM，Rodrigues D，et al. Investigation on solubilization protocols in the refolding of the thioredoxin TsnC from Xylella fastidiosa by high hydrostatic pressure approach [J]. Protein Expr Purif，2015， 106（3）：72-77.
[30] Zhang W，Yin K，Li B，et al. A glutathione S-transferase from Proteus mirabilis involved in heavy metal resistance and its potential application in removal of Hg2+ [J]. J Hazard Mater，2013，261（2）：646-652.