加味黄芪桂枝五物汤联合康复训练治疗脑卒中后肩-手综合征的效果

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Abstract Objective To investigate the effect of Jiawei Huangqi Guizhi Wuwu Decoction combined with rehabilitation training in the treatment of shoulder-hand syndrome (SHS) after stroke. Methods Ninety-six patients with SHS after stroke admitted to Beijing Hepingli Hospital from October 2017 to October 2019 were selected, they were divided into control group and study group according to the random number table method, with 48 cases in each group. The control group was given routine rehabilitation training, on basis of control group, the study group was given Jiawei Huangqi Guizhi Wuwu Decoction. The clinical efficacy, SHS scale (SHSS), Fugl-Meyer assessment (FMA), visual analogue scale (VAS), serum calcitonin gene-related peptide (CGRP), substance P (SP), bradykinin (BK) and adverse reactions were compared between the two groups. Results After treatment, the total clinical effective rate of the study group was significantly higher than that of the control group (P ＜ 0.05). After treatment, SP and BK in the two groups were lower than those before treatment, CGRP was higher than that before treatment (P ＜ 0.05). After treatment, SP and BK in the study group were lower than those in the control group, CGRP was higher than that in the control group (P ＜ 0.05). After treatment, the scores of SHSS and VAS in the two groups were lower than those before treatment, and the FMA was higher than that before treatment (P ＜ 0.05). After treatment, the scores of SHSS and VAS in the study group were lower than those in the control group, and the FMA was higher than that in the control group (P ＜ 0.05). During the treatment period no obvious adverse reactions were observed in the control group and one case of gastrintestinal discomfort occurred in the study group. Conclusion Jiawei Huangqi Guizhi Wuwu Decoction combined with rehabilitation training in the treatment of patients with SHS after stroke can effectively improve the clinical symptoms, the effect is significant, which may be related to the increase of CGRP content and the decrease of BK and SP levels.

Key words： Jiawei Huangqi Guizhi Wuwu Decoction Rehabilitation training Stroke Shoulder-hand syndrome Effect

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LIU Wei LI Bo LIU Jingfeng. Effect of Jiawei Huangqi Guizhi Wuwu Decoction combined with rehabilitation training in the treatment of shoulder-hand syndrome after stroke[J]. 中国医药导报, 2020, 17(32): 131-134.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I32/131

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