结缔组织病相关肺间质病变患者血清KL-6水平变化及临床意义

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Abstract Objective To investigate the changes of serum krebsvon den lungen-6 (KL-6) level in patients with connective tissue disease associated interstitial lung disease (CTD-ILD) and its clinical significance. Methods From May 2018 to October 2019, 80 cases with CTD-ILD treated in the Second People′s Hospital of Lianyungang of Jiangsu Province (“our hospital” for short) were selected as the CTD-ILD group, and 69 cases with CTD without ILD treated in our hospital during the same period were selected as the CTD-NILD group. Patients in the CTD-ILD group were further divided into usual interstitial pneumonia (UIP) group with 20 cases, nonspecific interstitial pneumonia (NSIP) group with 46 cases and undefined group with 14 cases according to high resolution CT result, and serum KL-6 level of each groups were compared. The correlation between serum KL-6 and lung function index was analyzed by Pearson method, and the diagnostic value of serum KL-6 level in CTD-ILD was analyzed by receiver operating characteristic (ROC) curve. Results The serum KL-6 level of the CTD-ILD group was higher than that of the CTD-NILD group, while maximum oxygen uptake (VO2max), lung diffusion capacity (DLco/SB) and lung dispersion per unit lung volume (DLco/VA) were lower than those of the CTD-NILD group (all P < 0.05). Serum KL-6 level in UIP group was higher than that in NSIP group and undefined group, and serum KL-6 level in NSIP group was higher than that in undefined group (all P < 0.05). Serum KL-6 level was negatively correlated with VO2max, DLco/SB and DLco/VA (r = -0.777, -0.711, -0.553, P < 0.05). ROC curve showed that the when cut-off value of serum KL-6 was 384.68 U/mL, the area under the curve was 0.832 (95%CI: 0.767-0.897), and the sensitivity and specificity were 0.81 and 0.87, respectively. Conclusion Serum KL-6 level in CTD-ILD patients is elevated abnormally, while lung function decreased significantly. The reduced lung function is closely related to the elevation of serum KL-6 level.

Key words： Connective tissue disease associated interstitial lung disease Krebsvon den lungen-6 Lung function High resolution CT

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