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| Relationship between amyloid β-protein and Alzheimer′s disease and the research progress of acupuncture intervention |
| LIANG Peizhe YANG Sha SHEN Yan ZHANG Baoyu WANG Shu |
| Institute of Acupuncture and Moxibustion, the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine National Clinical Medical Research Center of Traditional Chinese Acupuncture and Moxibustion Key Laboratory of Acupuncture Therapy for Encephalopathy, National Administration of Traditional Chinese Medicine Tianjin Key Laboratory of Acupuncture and Moxibustion Science, Tianjin 300381, China |
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Abstract Alzheimer′s disease (AD) is a neurodegenerative disorder characterized by cognitive impairment and memory loss. Amyloid β-protein (Aβ) is the initiating factor that triggers the course of AD, and a potential intervention for the treatment of AD is to reduce the deposition of Aβ in the brain. This paper summarizes the generation and cleanup of Aβ, and the relationship between Aβ and AD, and reviews the basic research on the regulation of Aβ by acupuncture in the treatment of AD. It is found that acupuncture can reduce the production of Aβ, promote the cleanup of Aβ by regulating Aβ-degrading enzyme and microglia-related factors, and improve the transport ability of the blood-brain barrier to Aβ and other pathways, and promote the dearance of Aβ. At the same time, the future research trends are prospected to provide new ideas for disease research.
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