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| Advancements of microRNA in diabetic nephropathy |
| TIAN Shasha1 YANG Xiaopeng1 GUO Hui1,2 |
1.Department of Nephrology, the Second Hospital of Shanxi Medical University, Shanxi Province, Taiyuan 030000, China;
2.Department of Nephrology, Shenzhen Baoan Shiyan People′s Hospital, Guangdong Province, Shenzhen 518005, China |
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Abstract Diabetic nephropathy (DN) is one of the main complications of diabetic microangiopathy and has been the leading cause of chronic kidney disease in China. It′s important to understand the pathogenesis and find new diagnostic and therapeutic targets of DN. MicroRNA (miRNA), as a ubiquitous non-coding small molecular RNA, is widely involved in gene post-transcriptional and epigenetic regulations. The expression or abnormal function play an important role in the occurrence and development of DN, mediating the pathophysiological changes such as the pathophysiological changes of renal tissue fibrosis, inflammation, podocyte apoptosis in DN. Recently, the value of miRNA in the early diagnosis and prognosis judgment of DN has been confirmed and it has been gradually used in clinical treatment as a therapeutic target for DN by inhibiting or reconstructing miRNA. However, there are great challenges of miRNA in the pathogenesis and clinical application for DN in the future.
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