|
|
|
| Clinical effect of Xiaoyao Powder addition and subtraction combined with Escitalopram Oxalate in the treatment of elderly patients with post-stroke depression and liver-depression type of fire |
| ZHAO Shichu1 LU Yanli1 TIAN Zhijun1 SONG Qingyang2 |
1.Department of Medical, Beijing Longfu Hospital, Beijing 100010, China;
2.Department of Geriatrics, Beijing Longfu Hospital, Beijing 100010, China |
|
|
|
Abstract Objective To investigate the clinical effect of Xiaoyao Powder addition and subtraction combined with Escitalopram Oxalate on depressive psychology and daily life ability in the elderly patients with post-stroke depression. Methods A total of 138 elderly patients with post-stroke depression in Beijing Longfu Hospital from February 2018 to November 2019 were selected and divided into the observation group and the control group according to the random number table method, with 69 patients in each group. The control group was treated with Escitalopram Oxalate only, while the observation group was treated with the combination of traditional Chinese and Western medicine treatment with Xiaoyao Powder addition and subtraction combined with Escitalopram Oxalate. After two courses (8 weeks) of treatment, the improvement of depression status, cognitive ability, life ability and social function of patients in the two groups were compared. Results After treatment, the Hamilton depression scale score in the observation group was lower than that of the control group, and the difference was statistically significant (P ＜ 0.05). The score of mini-mental state examination and the Barthel index of activity daily living in the observation group were higher than those in the control group, and the differences were statistically significant (all P ＜ 0.05). The comparison of functional activities questionnaire between the two groups showed no statistically significant difference (P ＞ 0.05). Conclusion The combination of traditional Chinese and Western medicine treatment with Xiaoyao Powder addition and subtraction combined with Escitalopram Oxalate in the elderly stroke patients is more effective in alleviating patients′ depression, improving their mental state and enhancing their activity daily living than the single use of Escitalopram Oxalate.
|
|
|
|
|
|
[1] Kim ES，Kim JW，Kang HJ，et al. Longitudinal impact of depression on quality of life in stroke patients [J]. Psychiatry Investig，2018，15（2）：141-146.
[2] 赵俊宏.老年人卒中后抑郁的初步调查[J].中国神经精神疾病杂志，2002，28（1）：49-50.
[3] 涂小敏.氟哌噻吨美利曲辛片联合氯硝西泮治疗丘脑卒中后抑郁的疗效分析[J].北方药学，2019，16（7）：108-109.
[4] 范鹏，赵铎.中西医对脑卒中后抑郁的认识与诊治[J].中医研究，2019，32（3）：7-9.
[5] 邵淋淋，宋水江，汤加利.丹栀逍遥散联合氢溴酸西肽普兰治疗脑卒中后抑郁29例[J].浙江中医杂志，2017，52（4）：260.
[6] 中华医学会神经病学分会，中华医学会神经病学分会脑血管病学组.中国急性缺血性脑卒中诊治指南2014[J].中华神经科杂志，2015，48（4）：246-257.
[7] 中华医学会精神科分会.中国精神障碍分类与诊断标准（CCMD-3）[M].济南：山东科学技术出版社，2001：86-87.
[8] 张明园.精神科评定量表手册[M].2版.长沙：湖南科学技术出版，1998：121-126.
[9] 金婷，张磊晶.我国常用的抑郁自评量表介绍及应用[J].神经疾病与精神卫生，2017，17（5）：366-369.
[10] 郑筱萸.中药新药临床研究指导原则[M].北京：中国医药科技出版社，2002：364-365.
[11] 周小炫.中文版简易智能精神状态检查量表在脑卒中患者中的信效度初步研究[D].福州：福建中医药大学，2015.
[12] 张丽君，黄奕平.脑血管病常规药物联合SSRI类抗抑郁药物治疗脑卒中后抑郁的疗效分析[J].中西医结合心脑血管病杂志，2020，18（3）：551-514.
[13] Folstein MF，Folstein SE，McHugh PR. “Mini-mental state”：A practical method for grading the cognitive state of patient for the clinician[J]. J Psychiatr Res，1975，12（3）：189-198.
[14] Katzman R，Zhang MY，Ouang-Ya-Qu，et al. A Chinese version of the Mini-mental state examination；Impact of illiteracy in a Shanghai dementia survey [J]. J Clin Epidemiol，1988，41（10）：971-978.
[15] 王丹，荣阳，荣根满.脑卒中后抑郁的相关因素及预后分析与临床研究[J].中国医药指南，2020，18（8）：151-152.
[16] Bezdicek O，Stepankova H，Martinec Novakova L，et al. Toward the processing speed theory of activities of daily living in healthy aging：normative data of the Functional Activities Questionnaire [J]. Aging Clin Exp Res，2016， 28（2）：239-247.
[17] 宋征宇，赵红梅，岳晓纹，等.多导睡眠图对脑卒中后疲劳和抑郁的评估[J].中西医结合心脑血管病杂志，2019， 17（22）：3643-3645.
[18] 聂婧，李霞.常见老年期器质性疾病所致抑郁的药物治疗[J].临床精神医学杂志，2019，29（3）：212-213.
[19] 濮捷，徐志鹏，汪志忠，等.艾司西酞普兰治疗脑卒中后抑郁的疗效研究[J].卒中与神经疾病，2019，26（6）：728-730.
[20] 韩艳茹，刘彩莉，贾奎.逍遥散结合黛力新治疗脑卒中后抑郁的临床疗效及对神经递质水平的影响[J].中医药信息，2019，36（6）：84-87.
[21] 张敏.柴胡加龙骨牡蛎汤治疗脑卒中后抑郁60例的疗效分析[J].中医临床研究，2019，11（7）：99-100.
[22] 魏巍，李香甜，戚文超.疏肝灸治疗脑卒中后抑郁症的临床研究[J].中西医结合研究，2019，11（4）：169-171.
[23] 曾宪晶，周金凤，谢根英，等.丹栀逍遥散联合针刺疗法对脑卒中后抑郁患者BDNF、5-HT表达的影响[J].中国老年学杂志，2019，39（7）：1562-1566.
[24] 王晓霞，赵颖丹，王明利.电项针结合逍遥散对脑卒中后抑郁的临床疗效及部分机制探讨[J].临床和实验医学杂志，2018，17（2）：155-159.
[25] 陈懿.丹栀逍遥散加减联合左金丸外敷涌泉穴治疗肝郁化火型失眠的临床观察[J].中医临床研究，2019，11（19）：77-79.
[26] 袁志兰.中医辨证联合黛力新对产后抑郁患者抑郁症状的影响[J].中国医药科学，2019，9（11）：42-45.
[27] 张锐丽，刘玥.丹栀逍遥散配合针灸治疗脑卒中后抑郁的临床效果[J].中医中药，2018，3（31）：138-139. |
|
|
|
