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| Mechanism of Lycii Fructus on the basis of network pharmacology |
| GUO Yanli1 LIU Weili1 WU Lihong1 JU Aixia2 SUN Shuang2 LI Qiuhong2 |
1.Experimental Training Center, Heilongjiang University of Chinese Medicine, Heilongjiang Province, Harbin 150040, China;
2.School of Pharmacy, Heilongjiang University of Chinese Medicine, Heilongjiang Province, Harbin 150040, China |
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Abstract Objective To study the main active components and targets of Lycii Fructus by network pharmacology, and speculate the possible pharmacological mechanism. Methods The bioactive components of Lycii Fructus were searched on the platform of BATMAN-TCM. The bioactive components were screened according to the criteria of oral bioavailability (OB)≥30% and drug like (DL)≥0.18, and the corresponding targets of the bioactive components were found. The purpose protein interaction network of active ingredients of Lycii Fructus was constructed, and the GO function enrichment and KEGG signal pathway enrichment were performed using the DAVID database. Results Forty-five kinds of active components that were OB≥30%, DL≥0.18 in Lycii Fructus were screened, among which, 36 active components had a total of 208 targets eliminating duplicates. In the DAVID database, performed under the condition of “P < 0.05, number of genes>10”, and 56 GO items of main biological functions of Lycii Fructus were obtained, 84 KEGG pathways were obtained. Conclusion The exploration of the multi-functional substance basis and multi-dimensional pharmacological effects of Lycii Fructus can provide reference for the further study.
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