|
|
|
| Effect of Propofol combined with Sevoflurane on brain index and cognitive function after general anesthesia in children |
| WU Shubao1 CHENG Wei2 |
1.Departmeng of Anesthesiology, Xinyi People′s Hospital, Jiangsu Province, Xinyi 221400, China;
2.the Affiliated Hospital of Xuzhou Medical University, Jiangsu Province, Xuzhou 221000, China |
|
|
|
Abstract Objective To observe the effect of Propofol combined with Sevoflurane anesthesia on brain index and cognitive function in children under general anesthesia. Methods According to the difference of anesthesia methods during operation, a total of 96 children undergoing general anesthesia in Xinyi People′s Hospital, Jiangsu Province were divided into simple group (epidural Propofol anesthesia) and compound group (epidural Propofol + laryngeal mask Sevoflurane anesthesia) with 48 cases in each group. The brain index between the two groups 1 min before anesthesia and 30 min after anesthesia, cognitive function scores before and 3 days after surgery, and adverse reactions during and after surgery were compared. Results Compared with 1 min before anesthesia, the brain index of children in the simple group were significantly reduced 30 minutes after anesthesia, while the composite group were significantly lower than those in the simple group, and the differences were statistically significant (P ＜ 0.05). Compared with before surgery, the Montreal cognitive assessment scale scores of children in the simple group were significantly decreased on 3 days after surgery, while the composite group were significantly higher than those in the simple group, and the differences were statistically significant (P ＜ 0.05). There was no statistically significant difference in the adverse reaction rate between the two groups (P ＞ 0.05). Conclusion Simple epidural Propofol general anesthesia has a certain effect on the brain index and cognitive function in children after surgery, but Propofol combined with Sevoflurane has little effect on the brain index and cognitive function in children after general anesthesia.
|
|
|
|
|
|
[1] 马敏，咸淑悦，曹玥，等.银杏提取物缓解丙泊酚麻醉大鼠海马组织损伤的机制研究[J].中国药师，2019，22（6）：1047-1052.
[2] 周斌，胡镐申，陈玲敏，等.腺相关病毒介导的小鼠发育期大脑中的特定细胞和特定脑区的基因编辑及潜在应用探索[J].临床和实验医学杂志，2019，18（3）：225-229.
[3] 任胤朋，骆磊，刘剑，等.MAC和AAA麻醉方法在脑功能区胶质瘤手术的应用研究进展[J].中华神经外科疾病研究杂志，2018，17（2）：188-189.
[4] 孔凡斌，杨芳，陈卫，等．蒙特利尔认知量表在脑小血管病患者认知功能障碍筛查中的作用[J].中华临床医师杂志，2016，5（23）：697-699.
[5] 张婧，陈岩，容俊芳，等.术后认知功能障碍影响因素的研究进展[J].中华老年多器官疾病杂志，2017，16（2）：113-116.
[6] 马艳辉，吴迪，田肇隆，等.两种麻醉方法用于恒河猴急性脑梗死模型麻醉效果的比较[J].首都医科大学学报，2018，39（4）：552-556.
[7] 王庆国.七氟醚复合麻醉对纯二尖瓣病变患者术后认知功能及神经功能的影响[J].中华心脏与心律电子杂志，2018，6（1）：28-30.
[8] 陈元良，徐丽丽，蓝志坚，等.七氟烷与丙泊酚联合右美托咪定对行腹腔镜胆囊切除术患者术后认知功能及氧化应激反应的影响[J].中华全科医学，2017，15（8）：1283-1285.
[9] Savage KJ，Al-Rajhi N，Voss N，et al. Favorable outcome of primary medi-astinal large B-cell lymphoma in a single institution：the British Columbia experience [J]. Ann Oncol，2016，17（1）：123-130.
[10] Seubert CN，Zhu W，Pavlinec C，et al. Developmental effects of neonatal isoflurane and sevoflurane exposure in rats [J]. Anesthesiology，2017，119（2）：358-364.
[11] 马丁.全身麻醉对老年患者腹部手术脑指数的影响[D].延吉：延边大学，2018.
[12] Kolb B，Mychasiuk R，Gibb R，et al. Brain development experience and behavior [J]. Pediatr BC，2016，61（16）：1720-1723.
[13] 宋金军，周竹晨，陈冰，等.丹参与红花水溶性成分配伍抗大鼠脑缺血再灌注损伤的作用研究[J].中华中医药学刊，2019，37（7）：1616-1619.
[14] Davidson AJ，Disma N，Graaff JC，et al. Neurodevelopmental outcome at 2 years of age after general anaesthesia and awake-regional anaesthesia in infancy（GAS）：an international multicentre，randomised controlled trial [J]. Lancet，2016，387（15）：239-250.
[15] 王国军，张琳成，陈冰，等.丹参中丹酚酸B对脑缺血再灌注损伤大鼠的保护作用研究[J].中华中医药学刊，2019， 37（7）：1566-1568.
[16] 薛国剑，郝建华，李平，等.右美托咪定对心脏瓣膜置换术患者脑代谢影响及脑保护作用[J].中华实用诊断与治疗杂志，2016，30（2）：193-195.
[17] 罗艳，姚尚龙，杨拔贤，等.中国麻醉医师在全身麻醉中七氟醚使用习惯的多中心研究[J].临床麻醉学杂志，2016， 32（1）：6-9.
[18] 蔡宜良，陈家趁，曹玉云，等.右美托咪定辅助七氟醚全身麻醉对患者血流动力学及氧化应激水平影响[J].现代医院，2019，19（10）：1506-1508，1510.
[19] 高宝华，王良山，陈展明，等.两种不同的吸入麻醉药用于小儿腭裂修复术麻醉效果比较[J].中国医学创新，2018， 15（27）：113-116.
[20] Ajay S，Renu S，Ajisha AD，et al. Comparison of low fresh gas flow technique to standard technique of sevoflurane induction in children，a randomized controlled trial [J]. Pediatric AM，2019，29（4）：1844-1856.
[21] 王红，刘聪霞.喉罩七氟醚吸入麻醉对腹股沟斜疝患儿术中应激反应及术后苏醒的影响[J].现代医用影像学，2019，14（3）：689-690.
[22] 王朝红.七氟醚联合少量舒芬太尼在新生儿手术麻醉中的效果观察[J].中外医学研究，2018，16（3）：123-125.
[23] 苏妙贤.小儿麻醉诱导过程中不同浓度七氟醚的应用效果分析[J].中国医药科学，2018，8（7）：159-162.
[24] 杨晓艳，刘杏，李清军，等.丙泊酚与七氟醚对老年腹部手术患者术后免疫功能、血液流变学及认知功能的影响[J].解放军医药杂志，2019，31（11）：84-88. |
|
|
|
