南充地区33 153名体检者幽门螺杆菌感染情况及其与动脉硬化危险因素的相关性分析

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Abstract Objective To analyze the prevalence of Helicobacter pylori (Hp) infection and the correlation with risk factors of atherosclerosis in physical examination population in Nanchong. Methods A total of 33 153 health examiners who underwent health examination from November 2015 to July 2019 in Health Management Center of Affiliated Hospital of North Sichuan Medical College were selected as the research subjects. According to the Hp infection, the examinees were divided into Hp positive group (13 948 cases) and Hp negative group (19 205 cases). The relationship between Hp infection and blood lipids, C-reactive protein, fasting plasma glucose, glycated hemoglobin, uric acid (UA), homocysteine (Hcy) were analyzed. Results There was no statistically significant difference in Hp infection rate among different age groups (P ＞ 0.05). Triacylglycerol (TG), very low density lipoprotein cholesterol (VLDL-C), UA and age of Hp positive group were higher than those of Hp negative group, high density lipoprotein cholesterol (HDL-C) was lower than that of Hp negative group, and the differences were highly statistically significant (P ＜ 0.01). Univariate logistic analysis showed that HDL-C and gender were protective factors for Hp infection (OR ＜ 1, P ＜ 0.01), while TG, VLDL-C, UA and age were risk factors for Hp infection (OR ＞ 1, P ＜ 0.01). Multivariate regression analysis showed that HDL-C was a protective factor for Hp infection (P ＜ 0.01). Conclusion Hp infection is associated with dyslipidemia. The higher the HDL-C value, the lower the possibility of Hp infection, which is a protective factor.

Key words： Helicobacter pylori Arteriosclerosis Blood lipid Risk factors

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	LI Yun1 LIU Juhua2 TIAN Weike1 LEI Rong1 LIU Mi1

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LI Yun1 LIU Juhua2 TIAN Weike1 LEI Rong1 LIU Mi1. Helicobacter pylori infection and the correlation with risk factors of atherosclerosis of 33 153 physical examinees in Nanchong[J]. 中国医药导报, 2020, 17(17): 53-56.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I17/53

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