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| Mechanism of Caulis Sinomenii on rheumatoid arthritis based on network pharmacology |
| DING Wencong1，2 HAN Longyin2 QIAN Kai2 LIN Changsong1 |
1.Department of Rheumatology and Immunology, the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Province, Guangzhou 510000, China;
2.the First Clinical School, Guangzhou University of Chinese Medicine, Guangdong Province, Guangzhou 510000, China |
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Abstract Objective To explore the pharmacological mechanism of Caulis Sinomenii in the treatment of rheumatoid arthritis (RA) through network pharmacology, and to provide theoretical basis for the clinical treatment of RA. Methods The retrieval time was from the establishment of the database to December 2018. Based on the TCMSP and TCMID database, the components and targets of Caulis Sinomenii were collected, and the component-target network was constructed through the software of Cytoscape. RA related targets were collected through TTD and Drug Bank data, and the target interaction (PPI) network was constructed in the STRING database. The common target of drugs and diseases was analyzed in Genomics database, and the signal pathway of common target was analyzed by using Cluego plugin in the software of Cytoscape. Finally, the component-target-pathway network diagram was constructed and analyzed. Results The therapeutic components of Caulis Sinomenii in the treatment of RA might be 16-epi-Isositsirikine, Stepholidine, Sinomenine, etc.; the therapeutic targets might include Jun proto-oncogene (Jun), Retinoid X receptor alpha (RXRA), peroxisome proliferative activated receptor gamma (PPARG), etc.; the key pathways included PPAR pathway, lipid metabolism regulation, PTEN gene transcription, nuclear cell receptor and transcription, etc.. Conclusion Caulis Sinomenii can relieve pain and inflammation and reduce bone destruction through multi components, multi targets and multiple pathways, which has a certain value for the treatment of RA.
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