血浆LP-PLA2水平与高血压患者危险分层及动脉粥样硬化程度的关系

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Abstract Objective To investigate the relationship between plasma lipoprotein related phospholipase A2 (LP-PLA2) level and the stratification and the degree of atherosclerosis (AS) in hypertensive patients. Methods A total of 100 cases of hypertension patients admitted to Minhang Branch of Shanghai Yueyang Integrated Traditional Chinese and Western Medicine Hospital (“our hospital” for short) from March 2016 to March 2019 were selected as the observation group, and another 100 cases of healthy personnel who received physical examination in our hospital during the same period were selected as the control group. The patients in the observation group were divided into low-risk group (16 cases), medium risk group (23 cases), high-risk group (21 cases) and extremely high-risk group (40 cases) according to the stratification standard of cardiovascular disease risk level. The basic data, blood lipid level, plasma LP-PLA2 and pulse wave velocity (PWV) levels were recorded. The correlation between plasma Lp-PLA2 and PWV in hypertension patients was analyzed. Results The levels of systolic blood pressure, diastolic blood pressure, low density lipoprotein and total cholesterol in the observation group were significantly higher than those in the control group, while the levels of triglyceride and high density lipoprotein were significantly lower than those in the control group ,and the difference was statistically significant (P ＜ 0.05). The levels of plasma LP-PLA2 and PWV in the observation group were significantly higher than those in the control group, and the difference was statistically significant (P ＜ 0.05). The levels of plasma LP-PLA2 and PWV of patients in the extremely high-risk group were significantly higher than the low-risk group, the medium-risk group and the high-risk group, and the difference was statistically significant (P ＜ 0.05). Pearson correlation analysis showed that plasma LP-PLA2 level was positively correlated with PWV level in hypertension patients (P ＜ 0.05). Conclusion The increase of plasma LP-PLA2 level in hypertension patients is closely related to the risk stratification and AS degree. The detection of plasma Lp-PLA2 level can guide the early treatment of patients.

Key words： Hypertension Atherosclerosis Lipoprotein associated phospholipase A2 Correlation Plasma

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	ZHANG Jun SUN Huifang LIU Xiaoli

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ZHANG Jun SUN Huifang LIU Xiaoli. Relationship between plasma LP-PLA2 level and the risk stratification and the degree of atherosclerosis in hypertensive patients[J]. 中国医药导报, 2020, 17(17): 141-144.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I17/141

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