盐酸右美托咪定在吸烟患者行肺癌根治术单肺通气中的肺保护作用

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Abstract Objective To investigate the lung protective effect of Dexmedetomidine Hydrochloride in one lung ventilation (OLV) of smoking patients undergoing lung cancer radical operation. Methods Forty smoking patients who underwent lung cancer radical operation in Jingmen First People′s Hospital in Hubei Province from September 2017 to September 2018 were selected as the study objects. According to the method of random number table, the patients were divided into control group and observation group, 20 cases in each group. In the observation group, 1 μg/kg Dexmedetomidine Hydrochloride was intravenously injected 10 min before anesthesia induction, and then 0.5 μg/(kg·h) was infused to 30 min before the end of operation. The control group was infused with the same volume of saline at the same speed. Before anesthesia induction (T0), immediately after OLV (T1), 60 min after OLV (T2), 30 min after recovery of bipulmonary ventilation (T3), and 2 h after operation (T4), the radial artery blood was taken, and the oxygenation index (OI) and respiratory index (RI) were calculated after the measurement of blood gas index; the concentrations of tumor necrosis factor-α (TNF-α) and intercellular adhesion molecule-1 (ICAM-1) were measured by enzyme-linked immunosorbent assay; the abnormal pulmonary function and the length of stay were recorded. Results Intra-group comparison: compared with T0, the control group at T2-T4 and the observation group at T2 and T3 the OI reduced and the RI increased significantly (P < 0.05); at T2-T4, the levels of TNF-α and ICAM-1 in the two group were significant increased (P < 0.05). Comparison between groups: compared with the control group, the OI of the observation group increased significantly and the RI decreased significantly at T2-T4 (P < 0.05); TNF-α and ICAM-1 levels in the observation group at T2-T4 significantly reduced (P < 0.05). Compared with the control group, the incidence of hypoxemia and pulmonary infection in the observation group was significantly reduced, and the length of stay was significantly shortened (P < 0.05). Conclusion Dexmedetomidine Hydrochloride can improve the ventilation and oxygenation function of the lung in OLV, protect the lung, reduce the incidence of inflammation and adverse reactions, and shorten the hospital stay.

Key words： Dexmedetomidine One lung ventilation Smoking Inflammatory factors

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	LIU Rongli YANG Changming▲ WANG Chan XIANG Longquan YUAN Zhenwu XIAO Di ZHANG Qin

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LIU Rongli YANG Changming▲ WANG Chan XIANG Longquan YUAN Zhenwu XIAO Di ZHANG Qin. The lung protective effect of Dexmedetomidine Hydrochloride in one lung ventilation of smoking patients undergoing lung cancer radical operation[J]. 中国医药导报, 2020, 17(16): 101-104,115.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I16/101

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