冠心病患者血尿酸水平与薄纤维帽粥样硬化斑块的关系

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Abstract Objective To investigate the relationship between serum uric acid (UA) levels and atherosclerotic plaque in thin-cap fibroatheroma (TCF) in patients with coronary heart disease. Methods A total of 110 patients with coronary heart disease admitted to Langfang People′s Hospital Affiliated to Hebei Medical University from March 2016 to March 2019 were selected as the research object. Based on the results of optical correlation tomography (OCT), they were divided into TCF group (35 cases) and non-TCF group (75 cases). Baseline data of patients were collected and biochemical indicators were detected. The relationship between UA and TCF was analyzed by logistic multivariate regression. Results The rate of the family history of coronary heart disease, body mass index, low density lipoprotein and UA levels in the TCF group were significantly higher than those in the non-TCF group, with statistically significant differences (all P ＜ 0.05). There was no significant difference between the two groups in age, sex, ratio of smoking history, ratio of drinking history, ratio of hypertension, ratio of diabetes, treatment, high density lipoprotein, triacylglycerol, total cholesterol, cardiac troponin, creatine kinase isoenzyme MB, hypersensitive C-reactive protein, B-type natriuretic peptide and creatinine (P ＞ 0.05). OCT test results showed that the thickness of fiber cap in the TCF group was significantly lower than that in the non-TCF group, while the ratio of lipid radians, plaque rupture and thrombus was significantly higher than that in the non-TCF group, with statistically significant differences (all P ＜ 0.05). However, there were no statistically significant differences between the two groups in the ratio of vascular calcification, the ratio of nourishing blood vessels, the ratio of plaque erosion, the minimum lumen area and the stenosis rate (P > 0.05). Correlation analysis showed that UA level in TCF group was significantly positively correlated with plaque rupture, thrombosis and ratio of lipid radians (r ＞ 0，P ＜ 0.05), while significantly negatively correlated with fiber cap thickness (r ＜0，P ＜ 0.05). Logistic multivariate regression analysis showed that UA, family history of coronary heart disease and LDL were independent risk predictors of TCF (all P ＜ 0.05). Conclusion UA level in patients with coronary heart disease was significantly correlated with TCF, plaque rupture and thrombosis, and UA level was an independent risk predictor of TCF.

Key words： Coronary heart disease Uric acid Atherosclerotic plaque in thin-cap fibroatheroma Optical coherence tomography

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	LI Yachao YANG Yanli AN Lei ZHANG Chunyan XUE Zengming

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LI Yachao YANG Yanli AN Lei ZHANG Chunyan XUE Zengming. Relationship between serum uric acid level and atherosclerotic plaque in thin-cap fibroatheroma in patients with coronary heart disease[J]. 中国医药导报, 2020, 17(14): 61-64,68.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I14/61

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