自拟活血续断汤治疗闭合性骨折效果及其影响因素分析

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Abstract Objective To explore the effect of Huoxue Xiuduan Decoction in the treatment of closed fractures, analyze the factors influencing the curative effect and the intervention strategies. Methods A total of 83 patients with closed fractures who were treated in Beijing Changping Hospital of Traditional Chinese Medicine from May 2016 to January 2018 were selected for observation and divided into the control group (41 cases) and the experimental group (42 cases) according to the random number table method. The control group was treated with conventional therapies such as closed reduction combined with splint external fixation, conventional antibiotics and bone protecting capsules. On the basis of the control group, the experimental group was treated with self-designed Huoxue Xiuduan Decoction. The clinical efficacy, inflammatory factors, pain and swelling degree of the two groups were observed. Logistic regression was used to test the influencing factors of the treatment effect of the experimental group. Results The total effective rate of the experimental group was higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). After treatment, the levels of interleukin-6 and interleukin-8 in the experimental group were significantly lower than those in the control group, with statistically significant differences (all P ＜ 0.05). After 1 day of treatment, there was no statistically significant difference between the two groups in pain score and swelling degree score (P ＞ 0.05). After 7 days of treatment, the pain and swelling degree scores of the two groups were lower than those after 1 day of treatment, and the experimental group was significantly lower than the control group, with statistically significant differences (all P ＜ 0.05). The reasons for the ineffective treatment in the experimental group were not correlated with gender, age, and cause of injury (P ＞ 0.05), and were correlated with the patients′ sleep time and whether they ate raw, cold, sour and spicy food (P ＜ 0.05). Logistic regression analysis showed that sleep time ＜ 8 h and frequent consumption of cold, sour and spicy food were risk factors for treatment failure (P ＜ 0.05). Conclusion The effect of self-designed Huoxue Xiuduan Decoction in the treatment of closed fracture is good, and it is worth popularizing in clinic. When using this treatment, the patient should follow the doctor's advice, follow a strict diet, and get enough sleep

Key words： Huoxue Xiuduan Decoction Closed fracture Logistic analysis

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	ZHU Kang WANG Xiaotong MA Hujing DU Haishan

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ZHU Kang WANG Xiaotong MA Hujing DU Haishan. Analysis of the effect of self-designed Huoxue Xiuduan Decoction in treatment of closed fracture and its influencing factors[J]. 中国医药导报, 2020, 17(12): 93-96.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I12/93

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