血清脂联素、胱抑素C与糖尿病肢体动脉闭塞症的糖脂代谢的关系

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Abstract Objective To investigate the correlation between serum adiponectin (APN) and cystatin C (CysC) on glucolipid metabolism in diabetic limb artery occlusion (DLAO). Methods From July 2017 to December 2018, 77 patients with the first stage or the second stage DLAO and 76 patients with diabetes mellitus (DM) admitted to Shanghai TCM-Integrated Hospital, Shanghai University of Traditional Chinese Medicine were selected as the study objects, named as DLAO group and DM group respectively. Body mass index (BMI), waist hip ratio (WHR) and serum total cholesterol (TC), triacylglycerol (TG), high-density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), apolipoprotein A1 (Apo-A1), apolipoprotein B (Apo-B), fasting blood glucose (FBG), glycosylated hemoglobin (HbA1c), CysC, APN levels were measured for all subjects. Logistic stepwise regression analysis with WHR, APN, CysC and Apo-A1 as independent variables was conducted for DLAO patients. Pearson correlation analysis was conducted between serum APN and BMI, WHR, course of diabetes, TC, TG, HbA1c, CysC. Results The levels of WHR and serum CysC in the DLAO group were significantly higher than those in the DM group. Serum APN and Apo-A1 in the DLAO group were significantly lower than those in the DM group, with statistically significant differences (all P ＜ 0.05). FBG, HbA1c, BMI, TC, TG, HDL-C, LDL-C and Apo-B of parents in the two groups showed no statistically significant differences (all P ＞ 0.05). Logistic stepwise regression analysis found that high serum APN was the independence protective factor for DLAO, while high serum CysC was the independence risk factor for DLAO (P ＜ 0.05). Pearson correlation analysis showed that serum APN level was negatively correlated with WHR, diabetes course, and serum CysC level (r ＜ 0, P ＜ 0.05), but not with BMI, TC, TG, and HbA1c (P ＞ 0.05). Conclusion Serum APN and CysC have a certain effect on glucolipid metabolism during the formation and development of DLAO.

Key words： Adiponectin Cystatin C Diabetic limb arterial occlusion Glucolipid metabolism

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	XU Liying FANG Yudong CAO Yemin ZHAO Manchen ZHOU Minjie

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XU Liying FANG Yudong CAO Yemin ZHAO Manchen ZHOU Minjie. The relationship between serum adiponectin, cystatin C and glucolipid metabolism in diabetic limb artery occlusion[J]. 中国医药导报, 2020, 17(1): 98-101.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I1/98

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