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| Diagnostic value of serum Hcy, ET-1 and urine U-mAlb/Cr ratio in early renal injury patients with preeclampsia |
| ZUO Jinling ZHANG Xiaoyu WANG Chunshuang CHEN Baoli YI Jianping |
| Department of Obstetrics and Gynecology, Tangshan Maternal and Child Health Hospital, Hebei Province, Tangshan 063000, China |
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Abstract Objective To explore the diagnostic value of serum homocysteine (Hcy), endothelin-1 (ET-1) and urinary microalbumin/creatinine (U-mAlb/Cr) in early renal injury patients with preeclampsia. Methods From March 2018 to May 2019, 95 cases of preeclampsia patients admitted to Tangshan Maternal and Child Health Hospital of Hebei Province were studied. According to the results of glomerular filtration rate, they were divided into abnormal renal function group (42 cases) and normal renal function group (53 cases). Another 60 healthy pregnant women were selected as control group. Serum levels of Hcy, ET-1, U-mAlb and urine Cr levels were detected. Results Compared with the control group, the levels of serum Hcy, ET-1 and urinary U-mAlb/Cr in the abnormal renal function group and the normal renal function group increased (P < 0.05). Compared with the normal renal function group, the levels of Hcy, ET-1 and U-mAlb/Cr in urine of the abnormal renal function group were increased (P < 0.05). Glomerular filtration rate, Hcy, ET-1 and U-mAlb/Cr were independent risk factors for early renal injury in preeclampsia patients. The AUC of Hcy, ET-1, U-mAlb/Cr and three combined diagnostic methods for ROC in early renal injury was 0.815, 0.774, 0.832 and 0.892, respectively, the sensitivity was 75.78%, 73.68%, 78.94%, 88.42%, and the specificity was 78.94%, 75.78%, 85.26% and 81.05%, respectively. Conclusion The levels of serum Hcy, ET-1 and U-mAlb/Cr increase after early renal injury in preeclampsia patients, and they have certain diagnostic value.
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