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| Study on prevention and treatment of atherosclerosis by compound Chinese medicine for reinforcing kidney based on PCSK9 targeting CD36, mediating RCT |
| JIA Qingling SHEN Dingzhu |
| Shanghai Geriatrics Institute of Chinese Medicine / Shanghai University of Traditional Chinese Medicine, Shanghai 200031, China |
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Abstract Atherosclerosis (AS) is the common pathological basis of cardiovascular and cerebrovascular events. Reverse cholesterol transport (RCT) plays an important role in the progress of AS. Proprotein convertase subtilisin/kexin type 9 (PCSK9) and cluster of differentiation 36 (CD36) are closely related to RCT. Combined with the preliminary research that compound Chinese medicine for reinforcing kidney can intervene AS, this paper intends to explore the research strategy that compound Chinese medicine for reinforcing kidney can prevent and cure AS by PCSK9 targeting CD36 and mediating RCT.
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