CD44V4和nm23在三阴性乳腺癌中的表达及其相关性

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Abstract Objective To explore the expression of CD44V4 and nm23 in triple negative breast cancer (TNBC) and their correlation in clinical prognosis. Methods Seventy TNBC patients admitted to Department of General Surgery, Liuzhou Municipal Liutie Central Hospital Guangxi Zhuang Autonomous Region (hereinafter referred to as "our hospital") from January 2010 to March 2015 were selected as the study group, and 70 non-TNBC patients in the same period in our hospital were selected as the control group. Immunohistochemistry was used to detect the expression of CD44V4 and nm23 in the cancer tissues of patients of two groups, and their correlation in the poor prognosis of TNBC was analyzed. Results The positive expression rate of CD44V4 in the study group was significantly higher than that in the control group, and the positive expression rate of nm23 in the study group was significantly lower than that in the control group. The differences were statistically significant (all P ＜ 0.05). The positive expression of CD44V4 in TNBC patients was correlated with vascular infiltration and lymph node metastasis (P < 0.05). The positive expression of nm23 was associated with lymph node metastasis (P ＜ 0.05). There was no significant correlation between CD44V4 and nm23 expression in TNBC cancer tissues (rs = -0.166, P ＞ 0.05). Conclusion The positive expression of CD44V4 in TNBC was up-regulated, while the positive expression of nm23 was down-regulated. The detection of the relationship between CD44V4, nm23 in TNBC and invasion, metastasis is of great value, and may become a new biomarker to judge the prognosis of TNBC.

Key words： Triple negative breast cancer CD44V4 nm23 Prognosis

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	LI Jun1 LI Chunying2

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LI Jun1 LI Chunying2. Expression and correlation of CD44V4 and nm23 in triple negative breast cancer[J]. 中国医药导报, 2019, 16(29): 100-103.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I29/100

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