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| Effect of Ginseng combined with Taohong Siwu Decoction on cardiac function and blood lipid in patients with coronary heart disease and angina pectoris |
| CHEN Jianhao WANG Jinliang ZENG Mingzhu |
| Department of Cardiology, Baiyun Branch of Guangdong Second Hospital of Traditional Chinese Medicine, Guangdong Province, Guangzhou 510080, China |
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Abstract Objective To investigate the effect of Ginseng combined with Taohong Siwu Decoction on cardiac function and blood lipid in patients with coronary heart disease and angina pectoris. Methods One hundred and one patients with coronary heart disease and angina pectoris admitted to Baiyun Branch of Guangdong Second Hospital of Traditional Chinese Medicine from September 2015 to June 2018 were selected. The patients were divided into control group (50 cases) and study group (51 cases) according to the random number table method. The control group was treated with routine comprehensive treatment, while the study group was treated with Ginseng combined with Taohong Siwu Decoction on the basiss of the control group. The changes of clinical efficacy, cardiac function index and blood lipid index were compared between the two groups, and the adverse reactions during treatment were observed. Results The total effective rate of the study group was 94.12% after treatment, which was significantly higher than that in the control group (74.00%), and the difference was statistically significant (P ＜ 0.05). After treatment, the left ventricular end-systolic diameter (LVESD) and left ventricular end-diastolic diameter (LVEDD) of the study group were significantly lower than that of the control group, and the left ventricular ejection fraction (LVEF) was significantly higher than that of the control group, and the differences were statistically significant (P ＜ 0.05). Compared with before treatment, LVESD and LVEDD were significantly decreased and LVEF was significantly increased in the two groups after treatment, and the differences were statistically significant (P ＜ 0.05). After treatment, the triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) in the study group were lower than those in the control group, and high density lipoprotein cholesterol (HDL-C) was significantly higher than that in the control group, the differences were statistically significant (P ＜ 0.05). Compared with before treatment, TG, TC and LDL-C were significantly decreased in both groups, and HDL-C was significantly increased, the differences were statistically significant (P ＜ 0.05). There was no significant difference in adverse reactions between the two groups during treatment (P ＞ 0.05). Conclusion Ginseng combined with Taohong Siwu Decoction in the treatment of patients with coronary heart disease and angina pectoris has a definite curative effect, which can effectively improve the cardiac function and blood lipid status of patients without increasing the incidence of adverse reactions. It has certain clinical application value.
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