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| Effect of health education combined with sex hormone supplement in 130 patients with functional hypothalamic amenorrhea |
| LI Jun1 MAO Lele2 BAI Wenpei2▲ |
1.Department of Obstetrics and Gynecology, Beijing Aerospace General Hospital, Beijing 100076, China;
2.Department of Obstetrics and Gynecology, Beijing Shijitan Hospital, Beijing 100038, China |
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Abstract Objective To observe the effect of health education combined with sex hormone supplement in the treatment of patients with functional hypothalamic amenorrhea (FHA). Methods From January 2016 to August 2017, 130 cases with FHA in the Gynecological Outpatient Department of Beijing Shijitan Hospital and Beijing Aerospace General Hospital were selected, including 70 cases of clear history of weight loss, 36 cases of mental stimulation and 24 cases of hyperactivity. After the exclusion of sex hormone contraindications, patients were treated with Fenmoxone (2/10) for 28 days, one course of treatment, all were treated for 6 courses of treatment. Five sex hormones, such as follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), testosterone (T), pituitary prolactin (PRL), and progesterone (P) were measured before and after 6 months of administration. The recovery of menstrual cycle and the improvement of symptoms were observed during the 6-12 months followe-up. Results There were 99 patients with menstruation recovery in 130 patients after treatment, and the total effective rate was 76.2%. The levels of FSH, LH and E2 decreased before administration, and LH decreased more significantly. The levels of FSH, LH, E2 and P increased to different degrees at 6 months after administration (P < 0.01). The level change of T and PRL was not obvious (P > 0.05). Compared with before administration, the uterine volume increased and endometrium thickened after 6 courses of administration, and the differences were highly statistically significant (P < 0.01). Conclusion Sex hormone supplementation while the health education can significantly improve the hormone level, uterine volume, endometrium thickening and recover menstruation as soon as possible in patients with functional hypothalamic amenorrhea, and prevent a series of problems caused by osteoporosis and genital atrophy, improve the low estrogen caused symptoms such as menopause syndrome.
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