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| Antiviral effect of Gankangjian 2 on HBeAg positive chronic HBV carriers and its effect on T lymphocyte subsets |
| ZHANG Shuangxi WANG Weiqiong HE Guomin QIU Lushan GUO Jieyi |
| The Second Department of Internal Medicine, Shunde Hospital, Guangzhou University of Chinese Medicine, Guangdong Province, Foshan 528300, China |
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Abstract Objective To evaluate antiviral effect of Gankangjian 2 on HBeAg positive chronic HBV carriers and its effect on T lymphocyte subsets. Methods Forty-three HBeAg positive chronic HBV carriers who met the inclusion criteria in Shunde Hospital of Guangzhou University of Traditional Chinese Medicine from June 2014 to January 2017 were selected and divided into treatment group (21 cases) and control group (22 cases) by using random number table method. Treatment group was given Gankangjian 2 orally, one package, three times a day. Control group was given Glucurolactone orally, 0.2 g, three times a day. Virological indices, T lymphocyte subsets, three routine and renal function between two groups were observed before treatment and 72 weeks of after treatment. Results After treatment of 72 weeks, serum HBV-DNA level in treatment group was lower than that before treatment and in control group, the difference was statistically significant (P < 0.05). After treatment of 72 weeks, serum HBeAg level in treatment group was lower than that before treatment and in control group, the difference was statistically significant (P < 0.05). There were no significant differences in CD3+, CD4+, CD8+, CD4+/CD8+ between and within two groups (P > 0.05). After treatment of 72 weeks, there were no significant abnormalities in blood routine, urine routine, fecal routine and renal function in two groups. Conclusion Gankangjian 2 can effectively reduce the quantitative values of HBV-DNA and HBeAg in HBeAg-positive chronic HBV carriers. Traditional Chinese medicine has a definite effect on inhibiting HBV replication and regulating immune tolerance of hepatitis B.
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