Notch1信号通路与宫颈癌血管生成拟态的相关性

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Abstract Objective To explore the correlation between Notch1 signaling pathway and vasculogenic mimicry (VM) in cervical cancer. Methods Paraffin sections were collected from 68 cervical cancer patients who underwent surgical treatment in Hubei Provincial Hospital of Traditional Chinese Medicine between January 2012 and December 2015 as cervical cancer group. Paraffin sections of normal cervix were also collected from 27 patients who were surgically treated for uterine leiomyoma as control group. CD31 immunohistochemistry and periodic acid-Schiff (PAS) reaction were performed to detect VM formation. IHC was performed to detect Jagged1, Notch1 and Hes1 expression. The correlations of VM with Jagged1, Notch1 and Hes1 were analyzed. The correlations of VM, Jagged1, Notch1 and Hes1 with patients′ clinic-pathological features and postoperative prognosis were analyzed. Results The positive expression rates of Jagged1, Notch1 and Hes1 in cervical cancer group were significantly higher than those in control group (P < 0.05). VM was only in cervical cancer tissues, with the positive expression rate of 39.7%. Jagged1 was associated with lymph node metastasis of cervical cancer (P < 0.05). Notch1 was associated with tumor size and tissue differentiation (P < 0.01). Hes1 was not associated with any clinic-pathological parameters of patients (P > 0.05). VM was associated with tumor size and lymph node metastasis (P < 0.01). VM was positively correlated with Jagged1 and Notch1 expression (r = 0.283, 0.304, all P < 0.05). VM was an independent risk factor for postoperative prognosis of cervical cancer patients (HR = 2.21, 95%CI: 1.85-2.64, P < 0.05). Conclusion VM formation in cervical cancer predicts patients′ poor postoperative prognosis. The up-regulated Jagged1/Notch1 signaling pathway in cervical cancer might be involved in promoting VM formation. In the future, targeted Notch1 pathway treatment might be expected to prevent VM formation in cervical cancer and improve patients′ prognosis.

Key words： Cervical cancer Vasculogenic mimicry Notch1 signaling pathway Immunohistochemistry

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	FANG Hong1 ZHOU Zhongming1 LI Yunjun1 LU Lin2

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FANG Hong1 ZHOU Zhongming1 LI Yunjun1 LU Lin2. The correlation between Notch1 signaling pathway and vasculogenic mimicry in cervical cancer[J]. 中国医药导报, 2019, 16(21): 88-92.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I21/88

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