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Advance in research on the effects of extracellular vesicles on the biological characteristics of tumor |
HE Ling1 ZHANG Xiaoyan2 YANG Yazhi3 LI Jian3▲ |
1.Clinical Department, Jiangxi Health Vocational College, Jiangxi Province, Nanchang 330052, China;
2.Medical College of Nanchang University, Jiangxi Province, Nanchang 330006, China;
3.Key Blood Laboratory, the Second Affiliated Hospital of Nanchang University, Jiangxi Province, Nanchang 330052, China |
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Abstract Tumor growth, invasion and metastasis depend on the "cross-talk" between tumor cells and stromal cells in their microenvironment, which mainly involves the secretion of soluble factors of these two kinds of cells, the release of membrane-tomont particles and the direct contact between cells. These vesicles are known as extracellular vesicles (EVSs), and tumor cells secrete more EVSs than normal cells, which separate proteins, DNA, RNA, and other "contents" into the body through both escrt-dependent and escrt-independent pathways. These "contents" facilitate the transmission of information between tumor cells and stromal cells, thus supporting tumor angiogenesis, invasion and metastasis, drug resistance, and malignant characterization of tumor cells.
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