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| Effects of low-frequency repetitive transcranial magnetic stimulation of different frequency on bone metabolism, lipid metabolism and quality of life of children with epilepsy |
| XU Bei1 WANG Guilan2 |
1.Department of General Pediatrics, the First Central Hospital of Baoding City, Hebei Province, Baoding 071000, China;
2.Department of Pediatrics, the First Hospital of Qinhuangdao City, Hebei Province, Qinhuangdao 066000, China |
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Abstract Objective To observe the effect of low-frequency repetitive transcranial magnetic stimulation (rTMS) of different frequency on bone metabolism, lipid metabolism and quality of life of children with epilepsy. Methods From March 2014 to March 2017, 156 children with epilepsy in the First Central Hospital of Baoding City were selected, and randomly divided into the control group (50 cases), 0.5 Hz group (53 cases) and 1.0 Hz group (53 cases). On the basis of the original antiepileptic treatment scheme， the control group was treated with sham stimulation, 0.5 Hz group was treated with rTMS of 0.5 Hz, and 1.0 Hz group was treated with rTMS of 1.0 Hz, all three groups were treated for 3 months. The seizure frequency of epilepsy and incidence of headache, bone metabolism indexes [calcium (Ca), phosphorus (P), alkaline phosphatase (ALP)], lipid metabolism indexes [total cholesterol (TC), triacylglycerol (TG), low density lipoprotein cholesterol (LDL-C)], and scores of the pediatric quality of life inventory measurement models (PedsQL4.0) before and after treatment in the three groups were compared. Results After treatment, the seizure frequency of epilepsy in the three groups was all lower than before treatment (P < 0.05), and the seizure frequency of epilepsy in the 1.0 Hz group was lower than those in the control group and 0.5 Hz group (P < 0.05), the incidence of headache in the three groups was compared, the difference was not statistically significant (P > 0.05). In levels of Ca, P, ALP, TC, TG and LDL-C in the three groups before and after treatment and between groups after treatment were compared, the difference were not statistically significant (P > 0.05). After treatment, The PedsQL4.0 each dimension score in three groups were higher than those before treatment (P < 0.05), and the 1.0 Hz group was higher than those of the control group and 0.5 Hz group(P < 0.05). Conclusion The rTMS of 1.0 Hz can reduce the seizure frequency of epilepsy and improve the quality of life of children. It has no obvious effect on lipid metabolism and bone metabolism in short term.
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