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| Relationship between homocysteine and threatened abortion， recurrent spontaneous abortion, secondary sterility |
| LI Menglan1 LIN Ning1 SHI Hui1 FENG Jie1 WU Yulin1 CUI Ting2▲ |
1.Jiangsu Institute of Planned Parenthood Research, Jiangsu Clinical Laboratory of Reproductive Health, Jiangsu Province, Nanjing 210036, China;
2.Department of Clinical Laboratory, the First Affiliated Hospital of Nanjing Medical University, Jiangsu Province, Nanjing 210029, China |
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Abstract Objective To investigate the relationship between homocysteine (Hcy) and threatened abortion, recurrent spontaneous abortion, secondary sterility. Methods From January 2017 to April 2018, in the First Affiliated Hospital of Nanjing Medical University, 194 cases of threatened abortion were selected as threatened abortion group, 364 cases of recurrent spontaneous abortion were selected as recurrent spontaneous abortion group, 547 cases of secondary sterility were selected as secondary sterility group, 500 cases of pregnant women were selected as normal pregnant group and 500 cases of pre-pregnancy women were selected as normal non-gestational group. The level of plasma Hcy, the percentage of Hhcy of each group and the relationship between Hcy and threatened abortion, recurrent spontaneous abortion, secondary sterility were compared and analyzed. Results Compared with the normal non-gestational group, the plasma Hcy level, percentage of Hhcy were significantly lower in the normal pregnant women group, while significantly higher in the recurrent spontaneous abortion group and the secondary sterility group, the differences were statistically significant (P < 0.01), and those in the threatened abortion group were tend to increase, but without statistically significant difference (P > 0.05). Compared with the normal pregnant group, the plasma Hcy level and the percentage of Hhcy were significantly higher in the threatened abortion group, recurrent spontaneous abortion group and the secondary sterility group, the differences were statistically significant (P < 0.01). The high Hcy level was the risk factor of threatened abortion (OR = 1.994), recurrent spontaneous abortion (OR = 4.095) and secondary sterility (OR = 3.006). Conclusion The plasma Hcy level has relationship with the threatened abortion, recurrent spontaneous abortion and secondary sterility, and the increase of plasma Hcy level could be an important risk factor of these diseases, more attention should be paid for clinical diagnosis and treatment.
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