右旋美托咪啶对室上性心动过速患儿七氟烷麻醉血流动力学及苏醒期躁动的影响

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Abstract Objective To investigate the effects of Dexmedetomidine on hemodynamics and restlessness during Sevoflurane anesthesia in children with supraventricular tachycardia. Methods A total of 63 cases of supraventricular tachycardia children who were treated with radiofrequency ablation in Beijing Huaxin Hospital, the First Affiliated Hospital of Tsinghua University from January 2013 to August 2017 were selected and divided into group A, B and C according to the random number table method, with 21 cases in each group. Before operation, children in group A were intravenously injected Dexmedetomidine 0.3 μg/kg, children in group B were injected Dexmedetomidine intravenously 0.5 μg/kg, and children in group C (control group) were injected with normal saline. The mean arterial pressure (MAP) and heart rate(HR) of T0, T1, T2, T3, T4 and T5 were observed and compared. The operation time, waking time, extubation time after treatment in 3 groups were recorded. The PAED scale and Watcha score were used to assess restlessness after awakening in these children. The incidence of > 15 min in the restless duration was recorded. Adverse reactions after the operation were recorded. Results Compared with T0, the MAP and HR from T3 to T5 in the group A and C increased with statistically significant differences (P < 0.05), and the differences on the MAP and HR in the group B at each time point was no statistically significant (P < 0.05). Compared with the group C, the MAP and HR from T3 to T5 in group A and B was decreased significantly (P < 0.05), and the MAP and HR in the group B was significantly lower than those of the group A. The scores of PEAD, Watcha and restless duration > 15 min in group A and B was lower than that in group C, and the scores group B was lower than that in group A, the differences of were statistically significant (P < 0.05). After treatment, the incidence of total adverse reactions in group A (23.80%) and group B (9.52%) were lower than that in group C (57.14%), and adverse reactions in group B were significantly lower than that in group A (P < 0.05). Conclusion Dexmedetomidine can effectively alleviate the restlessness in the awakening period of Sevoflurane in children with supraventricular tachycardia, improve hemodynamic changes, reduce the adverse reactions.

Key words： Dexmedetomidine Sevoflurane Hemodynamics Restlessness during recovery period

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	GUAN Yuan PANG Xiaolin ZHANG Dongya▲

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GUAN Yuan PANG Xiaolin ZHANG Dongya▲. Effects of Dexmedetomidine on hemodynamics and recovery during Sevoflurane anesthesia in children with supraventricular tachycardia[J]. 中国医药导报, 2018, 15(25): 96-99.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I25/96

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