哺乳动物雷帕霉素靶蛋白介导细胞自噬在肿瘤中的研究进展

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Abstract Autophagy capacity may correlate with malignant transformation and differentiation of cancer cells. The mammalian target of rapamycin (mTOR) has close relationship with autophagy, which can play an important role through regulating the autophagic activity on cancer genesis and progression. So far mTOR inhibitors (inhibiting targets of signaling pathways) have potential in the future for cancer therapy, the development of mTOR inhibitors represents an important field in anticancer research. This article summarizes the relationship between mTOR signaling pathway and tumor in autophagy pathways, and the current status of the development of mTOR inhibitors, it hopes to provide information for studies on cancer research and targets for tumor therapy.

Key words： Autophagy Tumor Mammalian target of rapamycin Therapy Research progress

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	ZHANG Haoran QIAO Xuxu BI Minghong

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ZHANG Haoran QIAO Xuxu BI Minghong. Research progress of cell autophagy mediated by mammalian target of rapamycin associated with tumor[J]. 中国医药导报, 2018, 15(25): 32-35.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I25/32

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