喘可治雾化吸入辅助治疗婴幼儿呼吸道合胞病毒毛细支气管炎的临床效果

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Abstract Objective To explore the clinical effect of Chuankezhi Atomization Inhalation in adjuvant therapy for respiratory syncytial virus bronchiolitis in infants. Methods Ninety infants with respiratory syncytial virus bronchiolitis from June 2015 to February 2017 in Maternity Hospital of Hangzhou City were selected and divided into two groups according to the random number table method, with 45 cases in each group. Patients in the control group were treated with clinical routine treatment plus Montelukast Chewing Tablets, while patients in the observation group were treated with Chuankezhi Atomization Inhalation on the basis of the control group. After treatment for 7 d, the pulmonary function indices (respiratory rate, tidal volume, peak tidal expiratory flow, inhalation time/total breathing time, serum cysteine), the level of inflammatory cytokines (CysLTs, LTE4), and the immune function index (CD4+/CD8+, T-IgE) of two groups were compared before and after treatment, and the total effective rate of the clinical treatments in two groups was calculated. Results The total effective rate of the observation group was 93.3%, higher than that of the control group (77.8%), the difference was statistically significant (P < 0.05). The value of RR and Ti/Tt in the observation group were significantly lower than those in the control group, the value of TV and tPTEF/tE were significantly higher than those in the control group, the differences were statistically significant (P < 0.05). The levels of serum LTE4 and CysLTS in the observation group were significantly lower than those of the control group, the differences were statistically significant (P < 0.05). The CD4+/CD8+ in the observation group was significantly higher than that of the control group, and the T-IgE was significantly lower than the control group, the differences were statistically significant (P < 0.05). Conclusion The application of Chuankezhi Atomization Inhalation in adjuvant therapy for respiratory syncytial virus bronchiolitis in infants can inhibit airway inflammatory reaction and improve lung function and immune function.

Key words： Infant bronchiolitis Respiratory syncytial virus Chuankezhi Injection Aerosol inhalation Immune function Pulmonary function Inflammatory cytokines

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YAO Qiang. Clinical efficacy of Chuankezhi Atomization Inhalation in adjuvant therapy for respiratory syncytial virus bronchiolitis in infants[J]. 中国医药导报, 2018, 15(18): 72-75,91.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I18/72

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