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| Effect of laparoscopic ovarian endometriosis cyst peeling surgery combined with Leuprolide on the ovarian reserve function of patients with ovarian endometriosis |
| MIN Aiping WU Yu |
| Department of Gynaecology and Obstetrics, the People′s Hospital of Leshan, Sichuan Province, Leshan 614000, China |
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Abstract Objective To discuss the effect of laparoscopic ovarian endometriosis cyst removal surgery combined Leuprolide on the ovarian reserve function of patients with ovarian endometriosis cyst. Methods A total of 112 patients with ovarian endometriosis cyst for operation treatment in Department of Gynaecology and Obstetrics of the People′s Hospital of Leshan were chosen from January 2013 to December 2015, which were divided into observation group and control group according to random number table method, 62 cases in the observation group , while 50 cases in the control group. The control group was treated with laparoscopic ovarian endometriosis cystectomy treatment, and the observation group was treated with Leuprolide on the base of the treatment of the control group with 3 cycles. Levels of anti Mullerian hormone serum follicle stimulating hormone (FSH), estradiol (E2), and CA125 were detected by radioimmunoassay. After 1 year of follow-up, the recurrence rate of cysts and ovarian reserve function were counted. Results The levels of AMH, FSH, E2 at preoperative and postoperative after 1 year had no statistical significance (P > 0.05). The number of basal follicles, ovarian volume and peak systolic flow velocity observed by transvaginal ultrasound were no significant difference between the two groups postoperative after 1 year (P > 0.05). And there was also no significant difference in the preoperative CA125 level between the two groups (P > 0.05). The levels of serum CA125 of the observation group was significantly lower than that of the control group 1 year after operation (P < 0.05). CA125 levels of the two groups between preoperation and postoperation were compared, and the differences were all statistically significant (P < 0.05). The recurrence rate of the observation group was lower than that of the control group 1 year after operation, the difference was statistically significant (P < 0.05). Conclusion Laparoscopic ovarian endometriosis cyst peeling surgery combined with Leuprolide can reduce the recurrence rate, and has no significant effect on ovarian reserve function, so it is worth in clinical promotion.
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