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| The gene phenotype, protein expression of TP53 gene in Uygur′s esophageal carcinoma and its correlation with prognosis |
| Abudoushalamu·Abudoureheman1 Madinyet·Niyaz2 ZHANG Haiping1 Julaiti·Ainiwaer1 Abudouaini·Tuerhong1 ZHANG Liwei1 Ilyar·Shayhedin1 Idiris·Awut1 |
1.Department of Thoracic Surgery, the First Affiliated Hospital of Xinjiang Medical University, Xinjiang Uygur Autonomous Region, Urumqi 830054, China;
2.Institute of Clinical Medicine, the First Affiliated Hospital of Xinjiang Medical University, Xinjiang Uygur Autonomous Region, Urumqi 830054, China |
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Abstract Objective To study the TP53 gene deletion and p53 protein expression level in Uygur′s esophageal carcinoma, and its correlation with prognosis of Uygur esophageal cancer patients. Methods Sixty-seven cases of Uygur esophageal squamous cell carcinoma treated by radical resection from December 2009 to June 2013 in Department of Thoracic Surgery, the First Affiliated Hospital of Xinjiang Medical University were selected. TP53 gene deletion and p53 protein expression was detected respectively by fluorescence in situ hybridization and immuno-histo-chemistry methods. The relationship of TP53 gene deletion and p53 protein expression with clinicopathological factors and postoperative survival rate was analyzed. Results In the highly differentiated group, the deletion rate of TP53 gene was 15.00%, which of moderate and poorly differentiation group was 40.43%, the difference was statistically significant (P ＜ 0.05). There was no significant difference of the deletion rate of TP53 gene in different tumor invasion depth and lymph node metastasis status (P ＞ 0.05). There was no significant difference of the degree of p53 protein expression in different degrees of tumor differentiation, tumor invasion depth and lymph node metastatis status (P ＞ 0.05). Conclusion There is a certain correlation between TP53 gene deletion and the differentiation degree of esophageal carcinoma tumor, but the relationship with the survival has not been determined. The TP53 gene deletion and p53 protein expression level cannot be seen as the prognostic biomarkers of Uygur patients with esophageal cancer. Therefore, larger sample capacity is needed for in-depth exploration and determination.
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