|
|
|
| Effect of different concentrations of the incidence and onset time of rate of Fentanyl-induced cough |
| WANG Maohua ZHANG Jing ZHAO Mengya CHEN Maogui ZHANG Zhuan SUN Xiaohong SUN Jianhong |
| Department of Anesthesiology, the Affiliated Hospital of Yangzhou University, Jiangsu Province, Yangzhou 225000, China |
|
|
|
Abstract Objective To investigate the effect of different concentrations of the incidence and onset time of rate of Fentanyl-induced cough. Methods From January to November 2017, 300 patients with general anesthesia for elective surgery in Affiliated Hospital of Yangzhou University were selected as research subjects. They were randomly divided into six groups using a random number table, non dilution control group A (group A1). One times dilute group A (group A2)︰ Fentanyl and normal saline 1︰1 were diluted and was uniform; 2 times dilute group A (group A3)︰ Fentanyl and normal saline 1︰2 were diluted and was uniform, and those three groups were injected at 5 s, non dilution control group B (group B1). One times dilute group B (group B2)︰ Fentanyl and normal saline 1︰1 were diluted and was uniform; 2 times dilute group B (group B3)︰ Fentanyl and normal saline 1︰2 were diluted and was uniform, and those three groups were injected at 10 s, with 50 cases in each group. The time of cough and the incidence rate of cough among the six groups were recorded and compared. Results When the concentration of the drug was the same and the speed of drug delivery was different, the cough onset time in group B1 were significantly longer than group A1 (P < 0.05). The incidence of cough in group B1 were significantly lower than group A1 (P < 0.05), the cough onset time in group B2 were significantly longer than group A2 (P < 0.05). The incidence of cough in group B2 were significantly lower than group A2 (P < 0.05), the cough onset time in group B3 were significantly longer than group A3 (P < 0.05). When the speed of drug delivery was the same and the concentration of the drug was different, compared with group group A1, there was no statistically significant differences of cough onset time in group A2 and group A3 (P > 0.05), the incidence of cough in group A2 were lower than group A1 (P ＜ 0.05), and the incidence of cough in group A3 were significantly lower than group A1 and group A2 (P < 0.05). Compared with group group B1, there was no longer of the cough onset time in group B2 (P > 0.05), and the incidence of cough in group B2 were lower than group B1, the differen (P < 0.05ce was statistically signifincant). Compared with group B1 and group B2, the cough onset time in group B3 were significantly longer than group B1 and group B2, and the incidence of cough in group B3 were significantly lower than group B1 and group B2, the differences were statistically significant (P < 0.05). Conclusion Reducing the speed of drug delivery and concentration of Fentanyl, which can prolonging the time of the cough onset time, reduce the incidence of cough, when the Fentanyl and normal saline 1︰2 were diluted and was uniform, which can significant inhibition of cough, thus it is significance to improve the safety of the patients′ anesthesia.
|
|
|
|
|
|
[1] Xu YJ，Zhu Y，Wang SL，et al. Dezocine attenuates fentanyl-induced cough in a dose-dependent manner-a randomized controlled trial [J]. Int J Clin Eexp Med，2015，8（4）：6091-6096.
[2] EL Baissari MC，Taha SK，Siddik-Sayyid SM，et al. Fentany linduced cough-pathophy siology and prevention [J]. Middle East J Anesthesiol，2014，22（5）：449-456.
[3] 万翠红，沈通桃.小剂量芬太尼预注减轻芬太尼诱发呛咳反应的临床观察[J].现代医学，2012，40（4）：456-458
[4] 张瑞冬，陈锡明，陈煜.芬太尼诱发呛咳的机制、影响因素和预防[J].国际麻醉学与复苏杂，2006，27（6）：369-372.
[5] 迟岩，徐咏梅.芬太尼诱发呛咳反应的治疗进展[J].实用医学，2012，28（14）：2299-2301
[6] 袁明峰，陈宇.地佐辛预防芬太尼诱发呛咳反应的效果[J].江苏医药，2015，41（18）：2176-2177.
[7] Choi SH，Min KT，Lee JR，et al. Determination of EC95 of remifentanil for smooth emergence from propofol anesthesia in patients undergoing transsphenoidal surgery [J]. Neurosurg Anaesth，2015，27（2）：160-166.
[8] 刘薇，严虹.盐酸纳美芬预防全麻诱导期舒芬太尼诱发呛咳的临床观察[J].中国药师，2017，20（3）：501-502，517.
[9] Tang QF，Qian YN，Zhang QW，et al. Effects of different priming doses of propofol on fentanyl-induced cough during anesthesia induction：a preliminary randomized controlled study [J]. U J Med Sci，2010，115（2）：121-124.
[10] 齐丹丹.盐酸羟考酮预防全身麻醉诱导中芬太尼诱发患者咳嗽的最小有效剂量[D].长春：吉林大学，2017.
[11] He L，Xu JM，Dai RP. Dexmedetomidine reduces theincidence of fentanyl-induced cough：a double-blind，randomized，and placebo-controlled study [J]. Ups J Med Sci，2012， 117（1）：18-21.
[12] Yu H，Yang XY，Zhang X，et al. The effect of dilution and prolonged injection time fentanyl-induced coughing [J]. Anaesthesia，2007，62（9）：919-922.
[13] Goyal VK，Bhargava SK，Baj B. Effect of preoperative incentive spirometry on fentanyl-induced cough： a prospective，randomized，controlled study [J]. Korean J Anesth?鄄esiol，2017，70（5）：550-554.
[14] 王磊，姚锦华，朱君健，等.优化全麻诱导用药预防患者芬太尼呛咳反应的观察[J].中华医学杂志，2010，90（13）：92l-923.
[15] Lin CS，Sun WZ，Chan WH，et al. Intravenous lidocaine and ephedrine，but not propofol，suppress fentanyl-induced cough [J]. Can J Anaesth，2004，51（7）：654-659.
[16] Chen YM，Chen WT，Liang S W，et al. Intravenous injection rate and site of fentanyl affect the incidence and onset time offentanyl-induced cough [J]. Nan Fang Yi Ke Da Xue Bao，2009，9（2）：339-340
[17] Soh S，Park WK，Kang SW，et al. Sex differences in remifentanil requirements for preventing cough during anes-thetic emergence [J]. Yonsei Med J，2014，55（3）：807-814.
[18] 崔旭蕾，马满娇，胡艳君，等.瑞芬太尼与右美托咪定用于预防全麻苏醒期呛咳反射及血流动力学波动的比较[J].基础医学与临床，2015，35（6）：812-816.
[19] Chen Y，Liang M，Zhu Y，et al. The effect of propofol and sevoflurane on the perioperative immunity in patients under laparoscopic radical resection of colorectal cancer [J]. Natl Med J Chin，2015，95（42）：3440-3444.
[20] Sun Z，Yang C，Cui Z，et al. Effect of intravenous dezocine on fentanyl-induced cough during general anesthesia induction：a double-blinded，prospective，randomized，controlled trial [J]. J Anesthesiol，2011，25（6）：860-863. |
|
|
|
