皮肤牵张器联合负压伤口治疗技术治疗大面积皮肤缺损创面的临床研究

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Abstract Objective To discuss the clinical effect of skin distractor combined with negative pressure wound therapy (NPWT) in the treatment of large area cutaneous defect wound (LACDW). Methods From January 2015 to June 2017, in Second Hospital of Qinhuangdao City, 61 patients with LACDW were selected, they were divided into observation group (31 cases) and control group (30 cases) according to the random number table. The control group was treated with NPWT technique, the observation group was treated with skin distractor on the basis of control group. The wound area, hyaluronic acid (HA) and vascular endothelial growth factor (VEGF), bacterial count of wound secretions in two groups were compared, the correlations of HA and VEGF levels with wound area and bacterial count of wound secretions were analyzed. Results The wound area and the bacterial count of the wound secretions in the two groups were gradually decreased after treatment, the wound area and the bacterial count of wound secretions on the 1st, 7th and 10th day after treatment in observation group was significantly smaller than the control group, the differences were statistically significant (P < 0.05). On the 10th day after treatment, the levels of HA and VEGF in the two groups were significantly higher than before treatment, the levels of HA and VEGF in observation group were significantly higher than the control group, the differences were statistically significant (P < 0.05). The result of Spearman correlation analysis method showed that the level of HA was negatively correlated with the wound area and the bacterial count of wound secretions (r = -0.688, -0.579, P < 0.05). The level of VEGF was negatively correlated with the wound area and the bacterial count of wound secretions (r =-0.623, -0.594, P < 0.05). Conclusion The clinical effect of skin distractor combined with NPWT in the treatment of LACDW is effective, it can effectively reduce the area of defect wound and bacteria count of wound secretions, and increase the levels of VEGF and HA, it is worth to be promoted.

Key words： skin distractor Negative pressure wound therapy Large area cutaneous defect wound

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	ZHU Hongwei1 YAN Mengyang1 ZHANG Yulong2 YU Yonglin3 SHENG Quanfeng1

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ZHU Hongwei1 YAN Mengyang1 ZHANG Yulong2 YU Yonglin3 SHENG Quanfeng1. Clinical study on skin distractor combined with negative pressure wound therapy in treating large area cutaneous defect wound[J]. 中国医药导报, 2018, 15(13): 59-62,71.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I13/59

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