|
|
|
| The relationship between human-induced protein 16 and preeclampsia |
| YE Yaoqun1 ZHEN Songbai2 LONG Jianling2 DONG Fucang2 |
1.Department of Obstetrics and Gynecology, Panyu District He Xian Memorial Hospital of Guangzhou, Guangdong Province, Guangzhou 511400, China;
2.Test Center Laboratory, Guangzhou Huayin Medical Testing Center Co. Ltd., Guangdong Province, Guangzhou 511400, China |
|
|
|
Abstract Objective To explore the relationship between human interferon-inducible protein 16 (IFI16) and the onset of preeclampsia (PE). Methods From June 2015 to March 2017, 125 patients with PE in Panyu District He Xian Memorial Hospital of Guangzhou ("our hospital" for short) were selected as the research group. In addition, 53 cases of healthy pregnant women in our hospital during the same period were treated as control group. The levels of IFI16 in serum and IFI16 protein expression in the placenta of pregnant women were detected by enzyme-linkedimmunosorbent assay and Western blotting respectively. The correlation between the level of IFI16 in serum and the expression of IFI16 in the placenta of pregnant women with PE was analyzed by Pearson. Results The levels of IFI16 in serum and the expression of IFI16 in the placenta of research group were significantly higher than those in the control group (t=17.580, 16.135, all P < 0.01). Compared with patients of mild PE, the level of IFI16 in serum and the expression of IFI16 in the placenta of patients with severe PE significantly increased (t=18.883, 14.845, all P < 0.01). There were no statistically significant differences of the level of IFI16 in serum and the expression of IFI16 in the placenta between early onset and late onset (t=0.360, 0.840, all P > 0.05). The expression levels of IFI16 in the serum of PE patients were positively correlated with the expression level of IFI16 in the placenta (r=0.725, P < 0.05). Conclusion The level of IFI16 in serum and the expression of IFI16 in the placenta of patients with PE are abnormally elevated, they are closely related to the disease development, which can be used as a clinical diagnosis of indicator and provide a new target for the treatment of PE.
|
|
|
|
|
|
[1] Cakmak M，Yilmaz H，Ba■lar E，et al. Serum levels of endocan correlate with the presence and severity of pre-eclampsia [J]. Clin Exp Hypertens，2016，38（2）：137-142.
[2] Gonzalez-Echavarri C，Villar I，Ugarte A，et al. Prevalence and significance of persistently positiveantiphospholipid antibodies in women with preeclampsia [J].J Rheumatol，2015， 42（2）：210-213.
[3] 章彩萍，朱敏，傅苏仙，等.干扰素-γ诱导蛋白10在子痫前期孕妇血清和胎盘组织中的表达及意义[J].中国现代医生，2017，55（15）：12-14，18.
[4] Taylor BD，Tang G，Ness RB，et al. Mid-pregnancy circulating immune biomarkers in women with preeclampsia and normotensive controls [J]. Pregnancy Hypertens，2016， 6（1）：72-78.
[5] 张展，王会平，石瑛，等.IFI16在子痫前期孕妇胎盘组织和血清中的表达及其与子痫前期发病的相关性[J].现代妇产科进展，2017，26（1）：11-14.
[6] 朱敏，王建芳，徐秋莲，等.IFN-γ诱导蛋白10及其受体在子痫前期孕妇血清和胎盘组织中的表达[J].浙江医学，2016，38（13）：1077-1080.
[7] 宋颖，杨孜，沈洁，等.规律产前检查子痫前期患者早期临床发病特点分析[J].中国实用妇科与产科杂志，2014， 30（6）：457-461.
[8] Bawadekar M，De Andrea M，LoCigno I，et al. The Extracellular IFI16 Protein Propagates Inflammation in Endothelial Cells Via p38 MAPK and NF-κBp65 Activation [J]. J Interferon Cytokine Res，2015，35（6）：441-53.
[9] Gugliesi F，Bawadekar M，De Andrea M，et al. Nuclear DNA sensor IFI16 as circulating protein in autoimmune diseases is a signal of damage that impairs endothelial cells through high-affinity membrane binding [J]. PLoS One，2013，8（5）：e63045.
[10] 谢幸，苟文丽.妇产科学[M].8版.北京：人民卫生出版社，2013.
[11] Kim CJ，Romero R，Chaemsaithong P，et al. Chronic inflammation of the placenta：definition， classification， pathogenesis， and clinical significance [J]. Am J ObstetGynecol，2015，213（4 Suppl）：S53-S69.
[12] Chen Q，Zhao M，Guo F，et al. The reduction of circulating levels of IL-6 in pregnant women with preeclampsia by magnesium sulphate and nifedipine：In vitro evidence for potential mechanisms [J]. Placenta，2015，36（6）：661-666.
[13] Haedersdal S，Salvig JD，Aabye M，et al. Inflammatory markers in the second trimester prior to clinical onset of preeclampsia，intrauterine growth restriction，and spontaneous preterm birth [J]. Inflammation，2013，36（4）：907-913.
[14] 孔艳，李小芳，孔祥，等.炎症-免疫因素与子痫前期发病机制研究进展[J].中华临床医师杂志：电子版，2016， 40（14）：2176-2179.
[15] Motylewska E，Lawnicka H，Kowalewicz-Kulbat M，et al. Interferon alpha and rapamycin inhibit the growth of carcinoid and medullary thyroid cancer in vitro [J]. Pharmacol Rep，2014，66（4）：624-629.
[16] 邹云莲，严新民.干扰素诱导蛋白家族成员IFI16在肿瘤中作用的研究进展[J].生命科学，2016，28（1）：100-106.
[17] 黄晶，宋方，龙向淑，等.干扰素诱导蛋白16对人脑血管外膜成纤维细胞增殖与迁移的影响及其机制[J].中国病理生理杂志，2013，29（4）：584-589.
[18] 肖燕，吴强.沉默干扰素诱导蛋白16对人主动脉外膜成纤维细胞凋亡的影响[J].贵州医科大学学报，2016， 41（5）：507-510.
[19] 龙向淑，吴强，宋方，等.干扰素诱导蛋白16siRNA对干扰素α诱导的人血管内皮细胞凋亡的影响[J].临床心血管病杂志，2015，31（2）：194-197.
[20] 曹天宇，李冰，邵帅，等.干扰素诱导蛋白16在银屑病患者皮损中的表达及其调控[J].中国皮肤性病学杂志，2016，30（3）：239-241，250. |
|
|
|
