外用米诺地尔与口服非那雄胺联合治疗男性雄激素性秃发的Meta分析

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Abstract Objective To review systematically the curative effect and safety of combined treatment with oral Finasteride and topical Minoxidil in male androgenetic alopecia (AGA). Methods The databases of PubMed, EMbase, Cochrane Library, CBM, WanFang, CNKI and VIP were retrieved for collecting RCT and CCT about combined treatment with oral Finasteride and topical Minoxidil in AGA before March 20th 2017, and reference lists were also searched. According to the inclusion and exclusion criteria, two reviewers screened and assessed independently the potential studies, and then the data was extracted. The data was given a Meta-analysis by using RevMan 5.3 software. Results Seven study articles were included, involving 1786 patients. The Meta-analysis showed: after 3 months of treatment, the clinical curative effect of the combination group in treating AGA was better than the Minoxidil group (OR = 1.95, 95%CI: 1.37-2.76, P = 0.0002) and the Finasteride group (OR = 2.30, 95%CI: 1.64-3.23, P ＜ 0.000 01). After 6 months of treatment, the clinical curative effect of the combination group in treating AGA was better than the Minoxidil group (OR = 2.20, 95%CI: 1.26-3.84, P = 0.005) and the Finasteride group (OR = 2.50, 95%CI: 1.46-4.30, P = 0.0009). After 12 months of treatment, the clinical curative effect of the combination group in treating AGA was better than the Minoxidil group (OR = 6.83, 95%CI: 2.92-15.99, P < 0.000 01) and the Finasteride group (OR = 2.77, 95%CI: 1.77-4.32, P ＜ 0.000 01). There were no serious adverse reactions in each group. Conclusion The combination treatment of Finasteride and topical Minoxidil has significant curative effect, and the safety is good.

Key words： Minoxidil Finasteride Androgenetic alopecia AGA Meta-analysis

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	ZHANG Shudan1 LI Qi2

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ZHANG Shudan1 LI Qi2. Meta-analysis of combined treatment with oral Finasteride and topical Minoxidil in male androgenetic alopecia[J]. 中国医药导报, 2018, 15(1): 109-113,149.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I1/109

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