激素性股骨头坏死发生机制的新认识

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Abstract The use of glucocorticoids is the most common non-traumatic cause of osteonecrosis of the femoral head. Studies have shown that glucocorticoids can act directly or indirectly. Direct effects include inhibition of osteoblast and osteoclast precursor formation, apoptosis of osteoblasts and osteocytes, prolongation of osteoclast lifespan and apoptosis of endothelial cells. Indirect effects include increasing the risk of clot formation, inhibiting angiogenesis, interfering with bone repair, causing local vessel contraction, promoting lipogenesis in the bone marrow and increasing intramedullary pressure. Multiple pathway activation leads to the decrease of blood supply of the femoral head, resulting in osteonecrosis. Besides, there are individual differences in steroid sensitivity and other underlying mechanisms. The disease model is a multiple hit theory. The more risk factors, the greater probability of disease. More work is needed to better discover the pathomechanisms of glucocorticoids in osteonecrosis, so as to provide better choice for clinical treatment.

Key words： Glucocorticoid Osteonecrosis of the femoral head Osteoblast Osteoclast Osteocytes Endothelial cell Apoptosis

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	DENG Shuang PENG Hao

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DENG Shuang PENG Hao. New understanding of pathogenesis of steroid induced osteonecrosis of the femoral head[J]. 中国医药导报, 2017, 14(34): 29-32.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2017/V14/I34/29

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