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| A study of rTMS treatment for ADHD patients evaluated by integrated visual and auditory continuous performance test |
| XUE Qing1,2 QI Xiaohong3 GAO Lehong1,2 MAO Wei1 WEI Rong3 LI Liping1,2 LIN Hua1,2 WANG Yuping1,2,3,4▲ |
1.Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China;
2.Beijing Key Laboratory of Neuromodulation, Beijing 100053, China;
3.Department of Pediatrics, Xuanwu Hospital, Capital Medical University, Beijing 100053, China;
4.Beijing Institute for Brain Disorders, Beijing 100069, China |
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Abstract Objective To explore the effect of rTMS for attention deficit hyperactivity disorder (ADHD). Methods 20 children and adolescents with ADHD treated in Neurology and Pediatrics Outpatient Clinics of Xuanwu Hospital, Capital Medical University from January 2013 to January 2016 were enrolled in the study. These patients were then divided into two groups randomly, each group had 10 cases. The active treatment group received active stimulation and the sham treatment group were given sham stimulation. The parameters of active condition was 0.5 Hz, 100% of the motor threshold, while the sham condition was 0.5 Hz, 10% of the motor threshold; the target was right parietal region; one course was 10 days. At the end of one-course treatment, integrated visual and auditory continuous performance test (IVA-CPT) was applied to assess the severity of ADHD, and the results were compared. Results In the active treatment group, compared with before treatment, auditory response time, correct auditory response, visual response time and correct visual response showed significant improvement after treatment (P < 0.05), however, no significant improvement of any parameter was revealed in the sham treatment group (P > 0.05). Between the two groups, significant differences were showed after treatment in auditory response time (P < 0.05), visual response time (P < 0.05) and correct visual response (P < 0.05), except correct auditory response (P > 0.05), but before treatment, these parameters had no significant differences between the two groups (P > 0.05). Conclusion Right parietal region low-frequency rTMS for ADHD children and adolescents can improve their clinical symptoms.
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