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| Effect of Huoxue Yishen Decoction combined with western medicine in the treatment of chronic glomerulonephritis |
| CHU Xu CHU Xiulin |
| Department of Nephrology, Xushui People's Hospital of Baoding City, Hebei Province, Baoding 072550, China |
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Abstract Objective To evaluate the clinical curative effect of Huoxue Yishen Decoction combined with western medicine in the treatment of chronic glomerulonephritis. Methods Eighty-six patients with chronic glomerulonephritis treated in Xushui People's Hospital of Baoding City from July 2014 to August 2016 were selected as research objects, and they were divided into two groups according to random number table method. 43 patients in the control group were treated with conventional therapy, and 43 patients in the combined group received conventional therapy + Huoxue Yishen Decoction. Before treatment and after treatment for 2 months, the TCM syndrome scores and the levels of serum creatinine (Scr) and blood urea nitrogen (BUN) between the two groups were compared, and the therapeutic effects of the two groups were evaluated. Results Compared with before treatment, the TCM syndrome scores in the two groups after treatment were decreased significantly, and the TCM syndrome score of combined group after treatment was significantly lower than that of control group, the differences were statistically significant (P ＜ 0.05). Compared with before treatment, the levels of Scr and BUN in the two groups after treatment were decreased significantly, and the levels of Scr and BUN in combined group after treatment were significantly lower than those in control group, the differences were statistically significant (P ＜ 0.05). The total effective rate of combined group was higher than that of control group, the difference was statistically significant (P ＜ 0.05). Conclusion Huoxue Yishen Decoction combined with western medicine in the treatment of chronic glomerulonephritis can significantly improve the clinical efficacy, relieve the clinical symptoms of patients, and promote the recovery of renal function.
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[1] 何宇，樊均明，马欣，等.活血化瘀方对慢性肾小球肾炎大鼠免疫调节作用及机制研究[J].中药材，2016，39（5）：1156-1159.
[2] 郭术莲，晋中恒，王建华，等.补肾清利活血汤联合奥美沙坦酯治疗慢性肾小球肾炎随机平行对照研究[J].实用中医内科杂志，2016，30（2）：54-56.
[3] Liao TD，Yang XP，Liu YH，et al. Role of inflammation in the development of renal damage and dysfunction in angiotensinⅡ-induced hypertension [J]. Hypertension，2008， 52（2）：256-263.
[4] Wang JP，Huang HQ，Liu PQ，et al. Inhibition of phosphorylation of p38MAPK involved in the protection of nephropathy by emodin in diabetic rats [J]. Eur J Pharmacol，2006， 28（553）：297-303.
[5] 杨芳.自拟中药芳化清利方联合西药治疗急性肾小球肾炎疗效观察[J].现代中西医结合杂志，2016，25（35）：3936-3939.
[6] 郑筱萸.中药新药临床研究指导原则（试行）[M].北京：中国医药科技出版社，2002.
[7] 唐晓斌，郭金琢，曹秋生.活血益肾汤加苯那普利治疗糖尿病肾病临床疗效观察[J].河北医学，2014，20（9）：1569-1570.
[8] Mc Alister FA，Zhang J，Tonelli M，et al. The safety of combiningangiotensin-converting-enzyme inhibitors with angiotensin-receptor blockers in elderly patients：a population-based lon-gitudinal analysis [J]. CMAJ，2011，183（6）：655-662.
[9] 马利平，贺蕾蕾.肾益康胶囊联合西药治疗脾肾亏虛型慢性肾小球肾炎随机平行对照研究[J].实用中医内科杂志，2016，30（5）：71-73.
[10] 曾明，程樱.黄芪注射液联合针灸穴位对慢性肾小球肾炎模型大鼠的治疗作用[J].医学导报，2014，33（1）：24-26.
[11] Park CM，Youn HJ，Chang HK，et al. YOP1and 2polysachardes form Taraxacun of ficinale，at-tenuate CC14-induced hepatic damage through the modula-tion of NF-κB and its regulatory mediators [J]. Food Chem Toxicol，2010， 48（5）：1255-1261.
[12] 何伟，陈明喆.五味异功散对慢性肾小球肾炎患者肾功能和血脂的影响[J].陕西中医，2016，37（9）：1142-1143.
[13] Kaczmarczyk K，Kosalka J，Soja J，et al. Rental interitial mast cell counts differ across classes of proliferative lupus nephritis [J]. Folia Histochem Cytobiol，2014，52（3）：218-224.
[14] Jin C，Zhang PJ，Bao CQ，et al. Protective effects of Atractylodes macrocephala polysaccharide on liver ischemia-reperfusion injury and its possible mechanism in rats [J]. Am J Chin Med，2011，39（3）：489-502.
[15] 王志强.益气温阳固精汤结合西医常规疗法治疗老年原发性慢性肾小球肾炎临床研究[J].国际中医中药杂志，2016，38（8）：697-700.
[16] 吕朋飞，刘计宁，黄同玉，等.中药灌肠、足浴联合西医治疗慢性肾小球肾炎失代偿期慢性肾衰竭疗效观察[J].现代中西医结合杂志，2015，24（28）：3082-3084.
[17] Li CQ，He LC，Jin JQ，et al. Atractylenolide Ⅰ and atractylenolide Ⅲ inhibit Lipopolysaccharide-induced TNF-alpha and NO production in macrophages [J]. Phytother Res，2007，21（4）：347-353.
[18] Nakao N，Seno H，Kasuga H，et al. Effects of combination treatment with losartan and trandolapril on office and ambulatory blood pressures in non-diabetic renal disease：a COOPERATE-ABP sub study [J]. Am J Nephrol，2004，24（5）：543-548.
[19] Hsu TW，Liu JS，Hung SC，et al. Renoprotective effect of renin-angiotensin-aldosterone system blockade in patients with predialysis advanced chronic kidney disease，hypertension，andanemia [J]. JAMA Intern Med，2014，174（3）：347-354.
[20] 罗志强.健脾益肾法佐治脾肾气虚型慢性肾小球肾炎的可行性分析[J].临床合理用药杂志，2015，8（14）：67-68. |
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