乌司他丁联合连续性肾脏替代疗法治疗急性重症胰腺炎的临床效果及对CRP、IL-6水平的影响

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Abstract Objective To investigate the clinical curative effect of Ulinastatin combined with early continuous renal replacement therapy in the treatment of severe acute pancreatitis. Methods 60 cases of patients with severe acute pancreatitis treated in Peking University Shougang Hospital from January 2015 to January 2016 were selected and divided into the combined group and the control group by random number table, each group had 30 cases. Patients of the two groups were treated with fasting, continuous gastrointestinal decompression, fluid infusion, somatostatin, anti-inflammatory, improving minicirculation; according to the condition, giving early enteral nutrition; noninvasive or invasive mechanical ventilation respiratory; giving Ulinastatin injection. Patients in the combined group were treated with continuous renal replacement therapy at the same time, continuous treatment of 14 days. The clinical efficacy of the two groups was compared, and the changes of CRP and IL-6 in the two groups before treatment and after treatment for 1, 3, 7 days were compared and analyzed. Results The total effective rate of the combined group was 93.3%, the total effective rate of the control group was 70.0%, there was statistically significant difference between the two groups (P < 0.05). There were no statistically significant differences in CRP and IL-6 levels before treatment between the two groups (P > 0.05). After treatment for 1, 3, 7 days, the CRP and IL-6 levels of the two groups were significantly lower than before treatment, and the CRP and IL-6 levels of the combined group were significantly lower than those of the control group, the differences were statistically significant (P < 0.05). Conclusion Ulinastatin combined with continuous renal replacement therapy in the treatment of severe acute pancreatitis can significantly improve the clinical efficacy, improvepatients′ inflammatory state by decreasing CRP and IL-6 levels, which is conducive to promote the recovery of the disease.

Key words： Severe acute pancreatitis Continuous renal replacement therapy Ulinastatin CRP IL-6

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	CHEN Xin CHENG Qipeng

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CHEN Xin CHENG Qipeng. Clinical effect of Ulinastatin combined with early continuous renal replacement therapy in the treatment of severe acute pancreatitis and its influence on CRP and IL-6[J]. 中国医药导报, 2017, 14(23): 122-125.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2017/V14/I23/122

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