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| Effect of different target concentration of Propofol on pharmacodynamics and pharmacokinetics of Mivacurium Chloride during perianesthesia of patients underwent microlaryngoscopic surgery |
| XU Yingyang GAO Guangjie LONG Xiaohong SHANG Yu |
| Department of Anesthesia, 463th Hospital of PLA, Liaoning Province, Shenyang 110042, China |
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Abstract Objective To compare the effect of of different target concentration of Propofol on pharmacodynamics and pharmacokinetics of Mivacurium Chloride during perianesthesia of patients underwent microlaryngoscopic surgery. Methods 60 cases of patients with ASA Ⅰ-Ⅱ underwent selective microlaryngoscopic surgery from June 2015 to September 2016 in 463th Hospital of PLA were selected, and divided into group Ⅰ, Ⅱ, Ⅲ by random number table, each gorup had 20 cases. The target effect-sit concentration of Propofol was 3.0, 4.0, 5.0 μg/mL respectively. After target controlled infusion of Propofol for 60 s, intravenous injection of Fentanyl 10 μg/kg, Mivacurium Chloride 0.2 mg/kg was given, and endotracheal intubation rapidly. Anesthesia was maintained with Remifentanil Hydrochloride 0.25 μg/(kg·min). Ulnar nerve train of 4 stimulation (TOF) was monitored continuously by using acceleration muscle relaxation monitor. Muscle relaxant indicators were recorded. Hemodynamics and BIS were monitored during the whole anesthesia. The pharmacokinetic effects of Mivacurium were measured. Results Comparison of the hemodynamic parameters in the three groups had no significant differences (P > 0.05). The onset time of Mivacurium in the three groups had no statistically significant difference (P > 0.05). 25%, 75%, 90% T1 recovery time of TOF and 70% T4/T1 recovery time in the group Ⅲ were significantly prolonged than those of the group Ⅰ, with statistically significant differences (P < 0.05). In the pharmacokinetic of Mivacurium, in addition to relative bioavailability (F), the rest of the indicators, compared with the groupⅠ, Ⅱ and group Ⅲ, the differences were statistically significant (P < 0.01). Conclusion The target effect-sit Propofol concentration and pharmacokinetics of Mivacurium has a dose-dependent correlation. Mivacurium pharmacodyn-amics is unsignificantly effected by target effect-sit propofol concentration of 4.0 μg/mL.
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