酮咯酸氨丁三醇联合喷他佐辛用于全身麻醉术后的镇痛疗效

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Abstract Objective To analyze analgesic effect of Ketorolac Tromethamin combined with Pentazocine after general anesthesia. Methods From February 2015 to February 2016, in Cangzhou People's Hospital, 200 patients treated with open surgery under general anesthesia in were selected, and they were divided into experiment group and control group according to the random number table method, 100 cases in each group. Patients in two groups were given PCIA after surgery, the experiment group was given Ketorolac Tromethamin 60 mg intramuscular at 30 min before surgery, control group was given equivalent normal saline. The degree of pain (VAS), the degree of sedation (Ramsay score) and the average pulse pressure (MAP), HR, SpO2 after operation of 1, 2, 4, 6, 8, 12, 24 h were observed, and PCIA pressing times and drug dosage after surgery 24 h were analyzed, and adverse reaction rates in the two groups were compared. Results VAS scores of two groups gradually decreased significantly at postoperative 1, 2, 4, 6, 8 h, and VAS scores of the experiment group were significantly lower than those in the control group (P < 0.05), and there were no statistically significant differences at postoperative 12, 24 h between the two groups (P > 0.05). There were no significant differences in Ramsay scores at postoperative 1, 2, 4, 6, 24 h between the two groups (P > 0.05), Ramsay scores at postoperative 8, 12 h in the experiment group were significantly higher than those in the control group (P < 0.05). PCIA pressing times and the dosage at postoperative 24 h in the experiment group were significantly lower than those in the control group (P < 0.05). MAP, HR at postoperative 2, 4 h in the experiment group were significantly higher than those at postoperative 1 h (P < 0.05), and MAP, HR at postoperative 2, 4, 6, 8 h in the control group were significantly higher than those at postoperative 1 h (P < 0.05). MAP, HR at postoperative 6, 8 h in the experiment group were significantly higher than those in the control group (P < 0.05), and there were no statistically significant differences in SpO2 at postoperative 1, 2, 4, 6, 8, 12, 24 h in the two groups (P > 0.05). Conclusion Ketorolac Tromethamin combined with Pentazocine can effectively reduce postoperative pain of patients with general anesthesia, with less adverse reactions and high safety.

Key words： Ketorolac Tromethamin Pentazocine Analgesic General anesthesia

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	YIN Fang LIU Aihua TIAN Lichuan ZHANG Huimin

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YIN Fang LIU Aihua TIAN Lichuan ZHANG Huimin. Analgesic effect of Ketorolac Tromethamin combined with Pentazocine after general anesthesia[J]. 中国医药导报, 2017, 14(16): 63-67.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2017/V14/I16/63

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