慢性阻塞性肺疾病的认知功能评价及其影响因素分析

Abstract
Figure/Table
References (25)
Related Citation (15)

Download: PDF (533 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To evaluate the cognitive function of patients with chronic obstructive pulmonary disease (COPD), and to analyze its influencing factors. Methods From February 2015 to July 2016, 68 patients with COPD admitted to Xinqiao Hospital, Third Military Medical University ("our hospital" for short) were selected as COPD group, and they were divided into mild-moderate group (37 cases) and severe group (31 cases) according to the severity of illness, 28 healthy persons in our hospital at the same time were selected as normal control group. The cognitive function of subjects were evaluated by mini-mental state examination (MMSE), the indexes of pulmonary function and arterial blood gas were detected respectively by pulmonary function detector and automatic blood gas analyzer. Results Compared with normal control group, the scores of MMSE and the indexes of pulmonary function in mild-moderate group and severe group decreased, the differences were all highly statistically significant (P < 0.01). The indexes of arterial blood gas PaO2, SaO2 in mild-moderate group were all lower than those of normal control group, the differences were all highly statistically significant (P < 0.01), while there was no significant difference of PaCO2 between mild-moderate group and normal control group (P > 0.05). The indexes of arterial blood gas PaO2, SaO2 in severe group were all lower than those of normal control group (P < 0.01), and PaCO2 was higher than that of normal control group, the difference was highly statistically significant (P < 0.01). Compared with mild-moderate group, the scores of MMSE and the indexes of pulmonary function in severe group decreased, the PaCO2 increased, the differences were all highly statistically significant (P < 0.01), there were no statistically significant differences of PaO2 and SaO2 between the two groups (P > 0.05). Pearson analysis showed that, the scores of MMSE in mild-moderate group were significantly positively correlated with PaO2 (r = 0.46, P < 0.05), the scores of MMSE in severe group were significantly positively correlated with FEV1 and PaO2 (r = 0.45, 0.40, P < 0.05). Conclusion The patients with COPD has obvious cognitive impairment, and the degree of cognitive impairment is correlated with severity of illness, among which, FEV1 and PaO2 are the important influencing factors of the occurrence of cognitive impairment in patients with COPD.

Key words： Chronic obstructive pulmonary disease Cognitive function Influencing factors

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	CHEN Xiaoyan1 LI Xiao2▲

Cite this article:

CHEN Xiaoyan1 LI Xiao2▲. Evaluation on the cognitive function of patients with chronic obstructive pulmonary disease and analysis on its influencing factors[J]. 中国医药导报, 2017, 14(16): 55-58.

URL:

http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2017/V14/I16/55

[1] 钱红玉，林红英，李毅，等.稳定期慢性阻塞性肺疾病患者的认知功能评价及其影响因素[J].中华结核和呼吸杂志，2014，37（10）：769-773.
[2] 刘春涛，冯玉麟.慢性阻塞性肺疾病全球创议：慢性阻塞性肺疾病诊断、管理和预防袖珍指南（2006年修订版）[J].中国呼吸与危重监护杂志，2007，6（3）：230-237.
[3] 李新玲，吴振国，朱颀峰，等.稳定期慢性阻塞性肺疾病患者的认知功能障碍研究[J].中国医药导报，2014，11（28）：39-42.
[4] 陈林，戴爱国，胡瑞成.核因子相关因子2及其蛋白激酶与γ谷氨酰半胱氨酸合成酶在慢性阻塞性肺疾病大鼠肺组织的表达[J].中华结核和呼吸杂志，2006，29（7）：487-488.
[5] 谢柏梅，傅卫红，徐朝霞，等.慢性阻塞性肺疾病大鼠呼吸、认知功能和海马区脑代谢物之间相关性研究[J].国际呼吸杂志，2015，35（5）：342-346.
[6] 袁娜娜，陈余清.慢性阻塞性肺疾病患者认知功能与抑郁、焦虑及BODE指数的关系[J].蚌埠医学院学报，2015， 40（5）：578-581.
[7] 桂心，谢小红，张仁荣，等.高同型半胱氨酸血症与脑梗死合并慢性阻塞性肺疾病患者认知障碍的相关性及药物干预研究[J].中国生化药物杂志，2015，35（4）：116-118， 121.
[8] Soysal TM，Ozalevli S，Dizdar G，et al. Determination of the relationship between cognitive function and hand dexterity in patients with chronic obstructive pulmonary disease （COPD）： a cross-sectional study [J]. Physiother Theory Pract，2015，31（5）：313-317.
[9] 中华医学会呼吸病学分会慢性阻塞性肺疾病学组.慢性阻塞性肺疾病诊治指南（2013年修订版）[J].全科医学临床与教育，2013，36（5）：67-80.
[10] 张友平，李明.慢性阻塞性肺疾病的治疗进展[J].中国医药科学，2011，1（20）：9-11.
[11] 李新玲，张立海，朱颀峰，等.慢性阻塞性肺疾病与患者认知功能的关系研究[J].河北医科大学学报，2015，36（3）：315-317.
[12] 胡玲玲，戈艳蕾，黄超，等.慢性阻塞性肺疾病患者血浆中性粒细胞明胶酶蛋白及内皮素-1水平与认知功能障碍的相关性[J].中华行为医学与脑科学杂志，2016， 25（9）：817-820.
[13] Zhang X，Cai X，Shi X，et al. Chronic obstructive pulmonary disease as a risk factor for cognitive dysfunction： a meta-analysis of current studies [J]. JAD，2016， 52（1）：101-111.
[14] 李靖，贾少丹，邵红，等.慢性阻塞性肺疾病合并抑郁症状相关因素及干预措施[J].中国现代医生，2015，53（20）：11-13.
[15] 赵云峰，姜艳平，程改存，等.圣乔治呼吸问卷和慢性阻塞性肺疾病评估测试问卷评价慢性阻塞性肺疾病稳定期患者健康相关生活质量的比较[J].上海医学，2013， 36（1）：47-51.
[16] 汪群.慢性阻塞性肺疾病大鼠模型海马区和血清中脑源性神经营养因子蛋白的表达变化[D].南京：东南大学，2012.
[17] 王兰，江莲，唐良法，等.慢性阻塞性肺疾病患者急性加重期认知功能障碍相关因素分析[J].中华老年医学杂志，2015，34（4）：391-393.
[18] 谢柏梅，王博，董玉，等.慢性阻塞性肺疾病患者的认知损害研究进展[J].陕西医学杂志，2015，44（1）：119-120.
[19] 高志欣，贠相华，王宏艳，等.慢性阻塞性肺疾病急性加重期患者认知障碍临床分析[J].齐齐哈尔医学院学报，2016，37（9）：1145-1147.
[20] 冯爱芳，王亮，李静，等.慢性阻塞性肺病诱导轻度认知功能障碍的回顾性队列研究[J].西安交通大学学报：医学版，2016，37（6）：867-871.
[21] Federman AD，Wolf MS，Sheng T，et al. Diminished cognitive function among chronic obstructive pulmonary disease patients during periods of acute illness exacerbation [J]. J Gerontol A Biol Sci Med Sci，2016，71（2）：279-280.
[22] 汪春荣，邱士军，沈比先，等.简易精神状态量表评分正常慢性阻塞性肺疾病患者脑认知功能研究[J].中国当代医药，2016，23（19）：36-39.
[23] Tulek B，Atalay NB，Yildirim G，et al. Cognitive function in chronic obstructive pulmonary disease: relationship to global initiative for chronic obstructive lung disease 2011 categories [J]. Respirology，2014，19（6）：873-880.
[24] 王素娟，赵玉娜，陈桂芝，等.慢性阻塞性肺疾病老年患者记忆功能及其影响因素[J].中国老年学杂志，2016， 36（6）：1492-1493.
[25] 汪春荣，刘勇，邱士军，等.稳定期慢性阻塞性肺疾病患者脑灰质体积的改变[J].中国医药导报，2016，13（28）：60-63.