沙丁胺醇气雾剂联合激素治疗哮喘的效果

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Abstract Objective To investigate the clinical efficacy of Salbutamol Aerosol combined with hormone in the treatment of asthma. Methods Ninety-four patients with bronchial asthma admitted to the First Affiliated Hospital of Dali University from March 2015 to March 2016 were selected as research objects, and they were divided into observation group (47 cases) and control group (47 cases) by random number table method. The patients of two groups were all treated with conventional treatment, including reducing phlegm, relieving cough, anti-inflammation and others. The control group was treated with Aminophylline Tablets 0.2 g, 2 times/d; Budesonide Aerosol, aerosolized inhalation, once 10 min, 3 times/d. On basis of control group, the observation group was treated with Salbutamol Aerosol, aerosolized inhalation, once 10 min, 3 times/d. Both groups were treated for 2 weeks. The clinical efficacy of the two groups after treatment was observed, the levels of lung function and the changes of C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), transforming growth factor-β1 (TGF-β1) and other indexes before and after treatment between the two groups were compared. Results The total effective rate of observation group was 93.6%, which of control group was 76.6%, the difference was statistically significant (χ2=5.371, P ＜ 0.05). After treatment, the forced expiratory volume in the first second (FEV1) and the percentage of forced expiratory volume in the first second occupied in the vital capacity (FEV1/FVC) in the observation group were all higher than those of control group, the differences were all statistically significant (t = 5.214, 6.104, all P ＜ 0.05). After treatment, CRP, TNF-α, TGF-β1 in the observation group were all lower than those of control group, the differences were all statistically significant (t = 22.383, 4.510, 18.996, all P ＜ 0.05). Conclusion β-receptor agonist Salbutamol combined with hormone Budesonide in the treatment of patients with asthma has exact effect, which can improve the lung function of patients, reduce the inflammatory reaction, so it can be as a reference for the clinical treatment.

Key words： β-receptor agonists Salbutamol Aerosol Hormone Asthma Effect

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	YANG Hua MA Jiqin LIU Jin

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YANG Hua MA Jiqin LIU Jin. Effect of Salbutamol Aerosol combined with hormone in the treatment of asthma[J]. 中国医药导报, 2017, 14(15): 152-155.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2017/V14/I15/152

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