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| Efficacy of Tranexamic Acid in treatment of irregular uterine bleeding caused by Depot-medroxyprogesterone acetat |
| ZHANG Xue LI Tianren GUO Yi |
| Department of Gynecology, First Hospital of China Medical University, Liaoning Province, Shenyang 110001, China |
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Abstract Objective To explore the efficacy and safety of Tranexamic Acid in treating irregular uterine bleeding secondary to Depot-medroxyprogesterone acetat. Methods From December 2015 to December 2016, in First Affiliated Hospital of Chinese Medical Sciences University, 80 patients with irregular uterine bleeding secondary to Depot-medroxyprogesterone acetat treatment were recruited. According to random number table, they were divided into treatment group and placebo group with 40 cases in each group, and they were treated with Tranexamic Acid and placebo respectively. All patients were followed up for 4 weeks, the outcomes were evaluated by the number of blood termination within 7 days and 28-day bleeding-free days and side effects reports were observed by information table. Results One case of the placebo group lost during follow-up, 33 cases (82.5%) in the treatment group and 10 cases (25.6%) in the placebo group stopped bleeding within 7 days after treatment initiation, the difference was statistically significant (P < 0.01). The 28-day bleeding-free proportion in treatment group was (20.73±4.07) d, that in the placebo group was (11.90±5.78) d, the difference was statistically significant (P < 0.01). One case of mild nausea was reported. Conclusion Tranexamic Acid is an effective and safe choice in dealing with irregular uterine bleeding secondary to Depot-medroxyprogesterone acetat treatment.
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