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| Screening of Mongolian anti-inflammatory drugs and its working mechanism study based upon the mitochondrial function |
| Xilinqiqige ZHANG Wen |
| Pharmacy Laboratory, International Mongolian Hospital, Inner Mongolia Autonomous Region, Huhhot 010065, China |
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Abstract [Abstract] As a traditional national medication, Mongolian medication has unique characteristics of national, geographical, theoretical and clinical characteristics. Mongolian drug has particular effect on anti-inflammation. However, the anti-inflammation mechanism of a variety of drugs is not clear due to limited modern science methodologies and techniques. In order to develop Mongolian anti-inflammation drug market and exploit its utilization, urgently require to find out an innovative research strategy and methodology. Mitochondria, an important organelle for cellular energy transduction, has been functionally linked to many kinds of metabolic and immunological diseases. From micro-systematic viewpoint, mitochondria are crucial factors for human physiological status. Digging into this factor through its interaction with the whole system, and also its response to external stimulation is always an important direction for research. And this theory is perfectly agreed with the idea of Mongolian medication. Uncoupling protein 2 (UCP2) and peroxisome proliferator-activated receptor-γcoactivator-1α (PGC-1α) are two important functional indicators for mitochondria. In this study, the expression and activity of both UCP2 and PGC-1α are analyzed to evaluate the mitochondrial status, and so as to check whether cells or tissues were normally functioning. Based on this study, a generalized research methodology for studying the physiology and selective active ingredients of Mongolian anti-inflammation drugs is presented and proved.
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