Correlation between Cytochrome P450 Enzyme 2E1 expression and Sevoflurane MACBAR in patients with passive smoking
XU Yongsheng1 LU Jingang2 XIA Zunping1
1.Department of Anesthesiology, the Fifth Hospital of Harbin City, Heilongjiang Province, Harbin 150040, China;
2.Department of Anesthesiology, Xixi Hospital of Hangzhou City, Zhejiang Province, Hangzhou 310023, China
Abstract：Objective To detect the change of CYP2E1 level in passive smoking patients and analyze its correlation with Sevoflurane MACBAR value. Methods From May 2017 to October 2017, in the Fifth Hospital of Harbin City, 90 patients with femoral head necrosis underwent artificial joint replacement under general anesthesia were selected. By inquiring the patients′ own tobacco exposure and combining with the content of cotinine, the patients were divided into passive smoking group (group A, 49 cases), non-smoking group (group B, 41 cases). Sevoflurane MACBAR was measured by single stimulus. HR, MAP before induction of anesthesia, 3 min and 1 min before cutting, 1 min and 3 min after cutting were recored. On the day before surgery, 5 mL of patients′ morning venous blood was gotten, centrifuged and all patients′ sera was collected for the detection of Cotinine and CYP2E1 content. Results In group A, the increase of average MAP value at 1 min and 3 min after skin incision was greater than that of group B, the difference was statistically significant (P < 0.05). The contents of Sevoflurane MACBAR, CYP2E1 and cotinine in group A were significantly higher than those in group B (P < 0.05). The CYP2E1 level in group A was positively correlated with MACBAR (r = 0.45, P < 0.05). Conclusion The level of CYP2E1 in passive smoking is correlated with MACBAR of Sevoflurane, it suggests that CYP2E1 in serum of passive smokers may affect the Sevoflurane MACBAR value.
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